Condition 1: Migraine. Condition 2: IBS. Migraine Irritable bowel syndrome
Conditions
Interventions
Intervention 1: Intervention group: IBS with Constipation. Patients in this group receive Venlafaxine 37.5 mg tablet daily plus probiotic capsule with Familact brand name which is the product of Zist
Sponsors
Zanjan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Confirmed migraine by ICHD3 criteria Confirmed IBS by Rome IV criteria
Exclusion criteria
Exclusion criteria: Affliction to gastrointestinal diseases other than IBS Affliction to neurologic diseases or headaches other than migraine Patients not referring to clinic after first visit IBS-D patients with contraindication to TCA IBS-C patients with contraindication to SNRI IBS patients not classified as IBS-C or IBS-D Consumption of antibiotics of any kind during study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Migraine severity. Timepoint: Severity of migraine is measured at day 0 and 90 of the trial. Method of measurement: Migraine severity is evaluated by Visual Analogue Scale.;Migraine frequency. Timepoint: Weekly. Method of measurement: Episodes of headache per week.;IBS severity. Timepoint: Severity of IBS is measured at day 0 and 90 of the trial. Method of measurement: Visual Analogue Scale from 1 to 10.;Number of analgesics consumed per week. Timepoint: Weekly. Method of measurement: Number of analgesics.;Aura. Timepoint: Migraine aura is determined at the first visit. Method of measurement: Presence or absence of aura. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Mahdi Maghbooli
Zanjan University of Medical Sciences
Outcome results
None listed