Melatonin add on anti epileptic drug

Evaluation of efficacy of Melatonin add on routine anti-epileptic drug regimen versus placebo in adult epileptic patients

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20101209005352N4

Enrollment

Registered

2021-02-18

Start date

2017-10-17

Completion date

Unknown

Last updated

2021-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

seizure. Epilepsy and recurrent seizures

Interventions

Intervention 1: Intervention group: Melatonin (patients prescribed 3mg melatonin tablet (add-on valproate) single dose daily, 1 hour before bedtime and continued for 8 weeks.). Intervention 2: Control

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Age range 18_45 years 1_4 general idiopathic tonic-clonic seizure attacks in the last 4 months Patients with a therapeutic level anti epileptic drugs

Exclusion criteria

Exclusion criteria: Patient dissatisfaction Patients are intubation Loss of consciousness Patients without a therapeutic level anti epileptic drugs

Design outcomes

Primary

Measure	Time frame
Frequency and severity of seizures. Timepoint: After 8 and 18 weeks of treatment. Method of measurement: According to Chalfont questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMehdi Maghbooli

Zanjan University of Medical Sciences

m.maghbooli@zums.ac.ir+98 24 3314 0233

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026