PPROM. Premature rupture of membranes, unspecified
Conditions
Interventions
Intervention 1: 250 mg vitamin C supplement was given to intervention group twice a day. ( 500 mg daily ) Patients were taking this supplement from 18 to 28 weeks of pregnancy. Intervention 2: Placebo
Prevention
250 mg vitamin C supplement was given to intervention group twice a day. ( 500 mg daily ) Patients were taking this supplement from 18 to 28 weeks of pregnancy.
Placebo which was produced with apparent drug profile of intervention group with the same frequency ( twice a day ) was prescribed to control group. Patients were taking placebo from 18 to 28 weeks of
Sponsors
Vice chancellor for research, Hamedan University of Medical Sciences and Health Services
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Pregnant women with gestational age 18 weeks who are suspicious of PPROM. Exclusion criteria: 1- Lack of follow up patients 2- Lack of cooperation of patients in taking the drug and placebo in time 3- History of surgery on uterus 4- History of cesarean section 5- Experience of artificial insemination pregnancy 6- Smoking 7- Short cervix
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Unconjugated estriol. Timepoint: Is measured once. Method of measurement: special laboratory kit.;Frequency of preterm premature rupture of membranes. Timepoint: 10 weeks after taking drug and plecebo. Method of measurement: questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Complications after delivery. Timepoint: be assessed after delivery. Method of measurement: questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Lavasani
Hamedan university of Medical Science and Health Service
Outcome results
None listed