acute mania. Mania without psychotic symptoms
Conditions
Interventions
Intervention 1: In the first group, during the 2 weeks titration phase, the Oxcarpazepine was started by 300 mg and increased every 2 days to a maximum dose of 900 to 2400 mg per days or the highest t
Treatment - Drugs
In the first group, during the 2 weeks titration phase, the Oxcarpazepine was started by 300 mg and increased every 2 days to a maximum dose of 900 to 2400 mg per days or the highest tolerated dose.
In the second group, Na Valporate was initiated by 600 mg/day and increased to a 20-36 mg/day or the highest tolerated dose for patients.
Sponsors
Mashhad University of Medical Scinces
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: For eligibility in the study patients had to be 18 to 60 years of age and with DSM- IV- TR axis I diagnosis of BMD-I in acute manic episode. Exclusion criteria included a primary diagnosis of Schizophrenia, delirium, anorexia nervosa, bulimia, autism, substance abuse, mental retardation and ADHD in recent 3 months. Other exclusion criteria were a history of epilepsy, a history of psychogenic polydipsia, a history of symptomatic hyponatremia and patients who were taking other antimanic medications during the study prior or within one week before it. Patients were required to be free of psychotropic drugs with exceptions of diphenhydramin or lorazapam for control of agitation and aggression. Risperidone 2-4 mg/day was prescribed for all of patients.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change of mood. Timepoint: base line,weeks 3,6. Method of measurement: Young Mania rating scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical Global Impression Scale. Timepoint: base line ,weeks 3 and 6. Method of measurement: change of scores. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Ali Talaei
Psychiatry and Behavioral Sciences Research Center, Ibn-e-Sina Hospital, Mashhad University of Medic
Outcome results
None listed