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Interdental Papilla Reconstruction Using I-PRF with and without Laser

Comparison of the interdental papilla reconstruction using I-PRF with and without laser: Randomised Clinical trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20101204005305N24
Enrollment
24
Registered
2025-12-14
Start date
2025-09-23
Completion date
Unknown
Last updated
2026-02-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Interdental papillary recession Tranow class I and II.

Interventions

Intervention 1: Intervention group: Injectable platelet-rich fibrin (I-PRF) will be prepared after taking 10 ml of the patients venous blood and centrifuging it for 4 minutes at a speed of 700 rpm. Fi

Sponsors

Kerman University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients over 18 years of age At least one papillary deficiency area of Class I or II according to the Tarnow-Nordland classification in the anterior region of the jaws Adjacent teeth in the area must be free of caries, calculus, and orthodontic appliances No bleeding on probing No deep periodontal pockets (greater than 5 mm) No tooth mobility Absence of gingivitis and periodontal disease in the affected area Plaque index below 20% Signed informed consent form

Exclusion criteria

Exclusion criteria: Pregnancy and breastfeeding Presence of coagulation disorders Use of medications that interfere with platelet function (e.g., NSAIDs) Use of medications that interfere with wound healing (e.g., corticosteroids, anticancer drugs) Any local or systemic condition contraindicating periodontal treatment Active infectious diseases (e.g., hepatitis, tuberculosis, HIV/AIDS) Smoking Patients undergoing orthodontic treatment Use of known medications that cause gingival overgrowth Use of traumatic toothbrushing techniques, hard toothbrushes, or abrasive toothpastes

Design outcomes

Primary

MeasureTime frame
Mean height of interdental papilla. Timepoint: Before I-PRF injection, and at one and three months after I-PRF injection. Method of measurement: By Image J software.;The distance to the dental contact point. Timepoint: Before I-PRF injection, and at one and three months after I-PRF injection. Method of measurement: By Image J software.;The overall surface area of the interdental papilla. Timepoint: Before I-PRF injection, and at one and three months after I-PRF injection. Method of measurement: By Image J software.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMina Habibolahpour

Kerman University of Medical Sciences

minahabibpur216@gmail.com+98 939 833 6334

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 7, 2026