Effects of Naloxane on Pain Control in Post operative Management of Hysterectomy Surgery

The effect of post-operative infusion of ultra-low dose of naloxone on post hystrectomy morphine consumption, side effects and pain intensity

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201012025175N4

Enrollment

Registered

2011-02-10

Start date

2010-12-02

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain. acute pain

Interventions

Intervention 1: Intervention: (Naloxone Group n=45 ) Before surgery, patients in group N received a loading dose of Naloxone (1ng. kg-1) then In the recovery room, patients were attached to a a

Treatment - Drugs

Intervention: (Naloxone Group n=45 ) Before surgery, patients in group N received a loading dose of Naloxone (1ng. kg-1) then In the recovery room, patients were attached to a a patient contr

Control group (n=45): Before the surgery, patients in this group received Saline, in 2 mL then in the recovery room, patients were attached to a patient controlled analgesia (PCA) device. The PCA devi

Eligibility

Sex/Gender

Female

Age

35 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 1-ASA physical status I and II scheduled for total abdominal hysterectomy with standadized general aneshteshia/ 2-Age between 35-65 years old Exclusion criteria : 1-Hepatic or Renal failure, Heart diseases, 2- history of drug allergy, substance abuse (including opioids and benzodiazepines) , 3-morbid obesity, 4-history of postoperative nausea and vomiting(PONV),history of motion sickness 5- smokers

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Morphine Consumption. Timepoint: 0 ,30 min,1hr, 2hr, 4hr, 8hr, 16hr, 20hr, 24hr after surgery. Method of measurement: Opioid registration by milligrams.;Pain Intensity. Timepoint: 0 ,30 min,1hr, 2hr, 4hr, 8hr, 16hr, 20hr, 24hr after surgery. Method of measurement: NRS( Numeric Rating Score).	—

Secondary

Measure	Time frame
Duration of operation. Timepoint: during the operation. Method of measurement: operating chart.;Intraoperative Fluid received. Timepoint: during the operation. Method of measurement: Crystaloid Fluid registration chart.;Pruritus. Timepoint: 0 ,30 min,1hr, 2hr, 4hr, 8hr, 16hr, 20hr, 24hr after surgery. Method of measurement: Numeric Rating score (NRS).;Post operative Nausea and Vomiting. Timepoint: 0 ,30 min,1hr, 2hr, 4hr, 8hr, 16hr, 20hr, 24hr after surgery. Method of measurement: NRS (Numeric Rating score).	—

Measure

Time frame

Duration of operation. Timepoint: during the operation. Method of measurement: operating chart.;Intraoperative Fluid received. Timepoint: during the operation. Method of measurement: Crystaloid Fluid registration chart.;Pruritus. Timepoint: 0 ,30 min,1hr, 2hr, 4hr, 8hr, 16hr, 20hr, 24hr after surgery. Method of measurement: Numeric Rating score (NRS).;Post operative Nausea and Vomiting. Timepoint: 0 ,30 min,1hr, 2hr, 4hr, 8hr, 16hr, 20hr, 24hr after surgery. Method of measurement: NRS (Numeric Rating score).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Ali Movafegh

Department of Anesthesiology,Tehran University of medical sciences

movafegh@sina.tums.ac.ir+98 21 8490 2372

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026