Comparative study of the effectiveness of oral phenytoin

A comparative study of the effectiveness of oral phenytoin and oral sodium valproate in the acute phase of mania in bipolar patients

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20101130005280N61

Enrollment

Registered

2023-03-23

Start date

2023-03-21

Completion date

Unknown

Last updated

2024-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

bipolar.

Interventions

Intervention 1: Intervention group:received oral phenytoin with an initial dose of 100 mg/d for one week, and if there is no response to the treatment after one week, the amount of 100 mg will be adde

Eligibility

Sex/Gender

All

Age

18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Patients with bipolar disorder in manic episode based on DSM-5 criteria Patients should be in the age range of 18 to 40 years To have the ability to perform and cooperate in psychological tests Absence of pregnancy and the postpartum period Not having severe medical illness, especially convulsions

Exclusion criteria

Exclusion criteria: History of drug sensitivity

Design outcomes

Primary

Measure	Time frame
Patient symptoms(behavioral stability and depression). Timepoint: Before the intervention and 48 hours after the intervention. Method of measurement: Based on daily visits and YMRS, CGI tests.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Manteghi

Mashhad University of Medical Sciences

raikaravan@gmail.com+98 903 926 4520

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026