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Effect of Folic Acid in Reducing Negative Symptoms of Male Schizophrenia Patients

Evaluating the Effectiveness of Adjunctive Therapy Using Folic Acid in Reducing Negative Symptoms of Male Schizophrenia Patients

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20101130005280N55
Enrollment
30
Registered
2022-07-09
Start date
2022-07-23
Completion date
Unknown
Last updated
2022-08-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Schizophrenia. Schizophrenia

Interventions

Intervention 1: Intervention group: The intervention group received 5 mg folic acid tablets for six weeks. Symptom severity was evaluated according to PANSS criteria at baseline and weeks 2, 4, and 6.

Sponsors

Gorgan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Schizophrenia Diagnosis Based on V-DSM Diagnostic Criteria Absence of Extrapyramidal Symptoms Male Gender Age Between 18 to 50 Years Old Completing Informed Consent to Participate in the Study

Exclusion criteria

Exclusion criteria: Clinically Prominent Neurological or Organic Disease Presence of Another Major I-Axis Diagnosis Based on V-DSM Abnormality in Previous Tests IQ Less than 70 Based on Standardized Tests History of Drug Use (Excluding Nicotine and Caffeine) ECT in the Past Two Weeks Oral Antipsychotics in the Past Week or Long-Acting Antipsychotics in the Past Month

Design outcomes

Primary

MeasureTime frame
Reducing Negative Symptoms. Timepoint: Before the intervention and after 6 weeks of drug use. Method of measurement: With PANSS test questionnaire, the process of improvement and reduction of symptoms is measured.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactElahe Mehdi Zade

Gorgan University of Medical Sciences

Raikaravan@gmail.com+98 17 3247 0110

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026