Condition 1: Heart rate changes due to Tracheal Extubation. Condition 2: Blood pressure changes due to Tracheal Extubation. Tachycardia, unspecified Elevated blood-pressure reading, without diagnosis of hypertension
Conditions
Interventions
Intervention 1: At the end of surgery and returning spontaneous breathing, all anesthetic agents will be discontinued and then the patients receive Esmolol 0.5 mg/kg bolus dose for 4 min before extuba
Prevention
Placebo
At the end of surgery and returning spontaneous breathing, all anesthetic agents will be discontinued and then the patients receive Esmolol 0.5 mg/kg bolus dose for 4 min before extubation and then in
At the end of surgery and returning spontaneous breathing, all anesthetic agents will be discontinued and then the patients receive normal saline with the same volume and order of active drugs.
At the end of surgery and returning spontaneous breathing, all anesthetic agents will be discontinued and then the patients receive Remifentanil 0.2µg/kg bolus dose for 4 min before extubation and the
Sponsors
Research Vice-Chancellor of Tabriz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion criteria: Adult patients, belonging to ASA (American Society of Anesthesiologist) I and II Class, undergoing elective Intracranial Mass Lesions surgeries Exclusion criteria: Pregnancy, heart rate below 60 bpm, systolic blood pressure below 100 mmHg, serious hepatic, renal and cardiovascular diseases, congestive heart failure, atrioventricular block, sick sinus syndrome, drug allergy and past history of ß_blocher intolerance, bronchospasm, asthma, chronic obstructive pulmonary diseases
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Heart rate. Timepoint: Before extubation, after extubation, each 5 min until discharge from recovery. Method of measurement: continuous ECG monitoring.;Oxygen saturation. Timepoint: Before extubation, after extubation, every 5 min until discharge from recovery. Method of measurement: pulse oxymetry devices.;Extubation time. Timepoint: after the surgery. Method of measurement: continuous ECG monitoring devices.;The time of opening of eyes. Timepoint: after the surgery. Method of measurement: continuous ECG monitoring devices.;The time of discharg of recovery. Timepoint: after the surgery. Method of measurement: continuous ECG monitoring devices.;Dyastolic blood pressure. Timepoint: Before extubation, after extubation, every 5 min until discharge from recovery. Method of measurement: non invesive monitoring devices with automatic cuff.;Systolic blood pressure. Timepoint: Before extubation, after extubation, every 5 min until discharge from recovery. Method of measurement: non invesive monitoring devices with automatic cuff.;Mean arteial blood pressure. Timepoint: Before extubation, after extubation, every 5 min until discharge from recovery. Method of measurement: non invesive monitoring devices with automatic cuff. | — |
Secondary
| Measure | Time frame |
|---|---|
| ECG changes. Timepoint: Before extubation, after extubation, every 5 min until discharge from recovery. Method of measurement: continuous ECG monitoring. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactHamzeh Hosseinzadeh
Tabriz University of Medical Sciences
Outcome results
None listed