Study of Effect of preoperative oral clonidine on nausea and vomiting after appendectomy surgery in children

Study of Effect of preoperative oral clonidine on nausea and vomiting after appendectomy surgery in children aged between 3-12 years in Bahrami hospital

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201011225225N1

Enrollment

Registered

2010-12-24

Start date

2011-03-01

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Appendicitis.

Interventions

Intervention 1: Intervention group: Clonidine, 4µg/kg orally in 20 ml apple juice, one hour before anesthesia induction. Intervention 2: Control group: 20 ml apple juice, one hour before anesthesia in

Treatment - Drugs

Placebo

Intervention group: Clonidine, 4µg/kg orally in 20 ml apple juice, one hour before anesthesia induction

Control group: 20 ml apple juice, one hour before anesthesia induction

Eligibility

Sex/Gender

All

Age

3 Years to 12 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: informed consent of parents, no contraindication for using study drugs, age 3 to 12 year old, scheduled for appendectomy, no history of motion sickness, digestive disorders, or other diseases related to nausea and vomiting, ASA class I & II Exclusion criteria: any history of drugs for nausea and vomiting and opioids during the 24 hours before surgery, need for a different anesthetic regimen, time limitation for delivering study drugs before surgery

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Nausea. Timepoint: frequency during the first 24 hours after surgery. Method of measurement: history taking from patient or parents or nurses.;Vomiting. Timepoint: frequency during the first 24 hours after surgery. Method of measurement: history taking from patient or parents or nurses.;Need for anti nausea and vomiting drug. Timepoint: frequency of nasea and vomiting during the first 24 hours after surgery. Method of measurement: information taken from patient's records.	—

Measure

Time frame

Nausea. Timepoint: frequency during the first 24 hours after surgery. Method of measurement: history taking from patient or parents or nurses.;Vomiting. Timepoint: frequency during the first 24 hours after surgery. Method of measurement: history taking from patient or parents or nurses.;Need for anti nausea and vomiting drug. Timepoint: frequency of nasea and vomiting during the first 24 hours after surgery. Method of measurement: information taken from patient's records.

—

Secondary

Measure	Time frame
Systolic and diastolic blood pressure. Timepoint: every 10 minutes during surgery and every 2 hours postoperatively. Method of measurement: mannometer.;Heart rate. Timepoint: continuously during surgery and every 2 hours postoperatively. Method of measurement: calculation of pulse rate.	—

Countries

Iran (Islamic Republic of)

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026