Hyperalgesia.
Conditions
Interventions
Intervention 1: first Intervention group (Remifentanil-Naloxone group ):patients receiving remifentanil 0.3 µg/kg/min and low dose naloxone 0.25 µg/kg/h in 50 ml normal saline. Intervention 2: Second
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Female patients aged between 18 to 75 years ASA (American Society of Anesthesiologists) I-II patients Patients scheduled for elective hysterectomy
Exclusion criteria
Exclusion criteria: Uncontrolled diabetes mellitus Neurologic disorders Psychologic disorders which needs treatment Inflammatory and renal diseases Drug abuse Routine use or taking NSAIDs, opioids or other analgesics 48 hours prior to surgery Allergy or contraindication to anesthetic agents or pain medications, including NSAID’s, acetaminophen and opioids History of any type of chronic pain needs medical or interventional treatments Patient who develop any surgical or anesthetic complication, or need reoperation Patients receiving ketamine, antipsychotic or gabapentinoids
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To decrease post operative hyperalgesia assessed by static tactile tests. The severity of pain in a static tactile test was reported as VAS. Timepoint: 0.5, 2, 6, 12, and 24 hours after surgery. Method of measurement: Static tactile test using a fine brush. | — |
Secondary
| Measure | Time frame |
|---|---|
| Total morphin dose used in post operative period. Timepoint: During the 24 hour period after surgery. Method of measurement: Reported in Mg showed by analgesia pump.;The time of first rescue dose of morphine in post operative period. Timepoint: In post operative period. Method of measurement: It is reported as the time interval to the end of surgery. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSeyed Mohammad Mireskandari
Tehran University of Medical Sciences
Outcome results
None listed