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Assessment the effect of nigella sativa oil on abnormal sperm parameters of infertile men

Assessment the effect of Nigella sativa L. seed oil on abnormal sperm parameters in infertile men: a randomized, double-blind, placebo-controlled clinical trial

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT201011205204N1
Enrollment
68
Registered
2011-06-25
Start date
2010-11-22
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

infertility. Male infertility

Interventions

Intervention 1: for Intervention group, nigella sativa oil BD/5 cc .daily use for each patient is 2.5cc oil for 60 days. Intervention 2: for control group use placebo 2.5cc BD including edible paraffi
Treatment - Drugs
Placebo
for Intervention group, nigella sativa oil BD/5 cc .daily use for each patient is 2.5cc oil for 60 days
for control group use placebo 2.5cc BD including edible paraffin for 60 days

Sponsors

Infertility research center of taleghani Shahid Beheshti medical university
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
20 Years to 45 Years

Inclusion criteria

Inclusion criteria: Inclusion conditions: 20-45years-old men diagnosed with infertility for more than a year; Volunteer in taking the mixture as treatment and having the consent; Whit no history of renal, hepatic or any chronic illnesses; The volunteers are not allowed to get any medical treatments; Semen samples, with lees than 30% morphology, lees than 50% motility and lees than type (a)motility . Also with the sperm count blow 20 x ml. Exclusion conditions: Men with ozoospermia; gonad abnormalities or varicocell; suffering from urinary retention or infections; those who have taken hormone treatment; evidence of male accessory gland infection; any recent medical or surgical illness; hormone treatment for promoting fertility in the last three months; those who have time limitation (e.g. those whose wives are above 35) and cigarette smoking were excluded

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Morphology. Timepoint: Before intervention & 2 months after. Method of measurement: Staining & microscope.;Viscosity. Timepoint: Before intervention & 2 months after. Method of measurement: Pipet pastor.;Round cells. Timepoint: Before intervention & 2 months after. Method of measurement: Lam & microscope.;Semen volume. Timepoint: Before intervention & 2 months after. Method of measurement: Syringe or folkone tube.;Sperm count. Timepoint: Before intervention & 2 months after. Method of measurement: Lam & microscope.;Motility. Timepoint: Before intervention & 2 months after. Method of measurement: Lam & microscope.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Kolahdooz

Shahid Beheshti Medical University, Koodakyar Ave., Daneshju Blvd., Velenjak, Tehran, IRAN

mary.kolahdooz@yahoo.com+98 21 3626 1871

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026