Brain trauma. Intracranial injury
Conditions
Interventions
Intervention 1: Administration of Tranexamic acid 1 gr in 100 ml serum as loading dose and then 1 gr in 1000 ml serum during 8 hours. Intervention 2: Administration of Normal Salin same as interventio
Treatment - Drugs
Administration of Tranexamic acid 1 gr in 100 ml serum as loading dose and then 1 gr in 1000 ml serum during 8 hours
Administration of Normal Salin same as intervention group
Sponsors
Vice chancellor for research, Kashan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
15 Years to 70 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Any traumatic brain lesion in CT scan such as sub arachnid hemorrhage, intra Cranial hemorrhage, subdural hemorrhage …; age 15 years and more; non penetrating trauma; the first CT scan within 8 hours after trauma; no need to brain surgery during 8 hours. Exclusion criteria: patients with coagolopathy; serum creatinine more than 2 mg; massive organs injury; hospital admission after 8 hours from trauma; pregnant patients; drugs which induced coaglopathy; patients who are unable to perform secondary CT scan.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hemorrhagic Mass size. Timepoint: Before and 24 hours after drug administration. Method of measurement: Using CT scan.;The effect of mass on brain tissue. Timepoint: Before and 24 hours after drug administration. Method of measurement: Using CT scan.;Adverse effect of tranexamic acid. Timepoint: During drug administration till one week. Method of measurement: Observation and patient examination. | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient recovery status. Timepoint: 3 months after patient discharge. Method of measurement: Based on GCOS. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMasoumeh Abedzadeh Kalahroudi
Kashan University of Medical Sciences
Outcome results
None listed