Contrast Induced Nephropathy. Acute renal failure (includes acute renal impairment)
Conditions
Interventions
Intervention 1: Intervention arm: Pentoxifylline (Trental) 400 mg PO three times a day for 24 hours before and 24 hours after PCI+1 ml/kg/h of 0.9 saline for 6 hours prior to and 6 hours after the pro
Prevention
Intervention arm: Pentoxifylline (Trental) 400 mg PO three times a day for 24 hours before and 24 hours after PCI+1 ml/kg/h of 0.9 saline for 6 hours prior to and 6 hours after the procedure
Control arm: 1 ml/kg/h of 0.9 saline for 6 hours prior to and 6 hours after PCI
Sponsors
Vice-chancellor for Research Affairs, Shiraz University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Eligibility was defined as the age between 18 and 65 years and baseline serum creatinine=1.5 mg/dl. Exclusion criteria were acute myocardial infarction, congestive heart failure, hemodynamic instability during or after procedure, known allergy or previous administration of pentoxifylline and use of concomitant nephrotoxic agents and diuretics.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum creatinine. Timepoint: 24 hours before intervention and 48 hours after PCI. Method of measurement: Blood test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactJamshid Roozbeh
Shiraz Nephro-urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Outcome results
None listed