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Effect of Ibuprofen, dexamethasone and placebo on lower jaw nerve anesthesia

Effect of Premedication of Ibuprofen and Dexamethasone on the Success of Inferior Alveolar Nerve Block for Teeth with Irreversible Pulpitis

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT201011085141N1
Enrollment
210
Registered
2012-04-02
Start date
2012-03-15
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Irreversiblae pulpitis. Diseases of pulp and periapical tissues

Interventions

Intervention 1: intervention group (Dexamethasone) 0.5 mg 30 min before injection. Intervention 2: intervention groups (Ibuprofen ) 400 mg 30 min before injection. Intervention 3: control group (pl
Treatment - Drugs
Placebo
intervention group (Dexamethasone) 0.5 mg 30 min before injection
intervention groups (Ibuprofen ) 400 mg 30 min before injection
control group (placebo: Lactose) 30 min before injection

Sponsors

Periodontal and dental research center
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 50 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: healthy patients having a first or second mandibular molar tooth with irreversible pulpitis and normal periapical radiographic appearance. Exclusion criteria: the presence of systemic disorders, a sensitivity to lidocaine with 1:80,000 epinephrine; a sensitivity to NSAIDs; nasal polyp; a history of gastrointestinal ulcers; the presence of widening of the periodontal ligament space; the presence of a periapical radiolucency; lactation, pregnancy; using any type of analgesic medication in the preceding 12 hours before the treatment; having a tooth not suitable for restoration, and having a full crown.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Inferior alveolar nerve block. Timepoint: 45 minute after intervention (15 minute after injection). Method of measurement: visual analoge scale.

Secondary

MeasureTime frame
Analgesia during access cavity preparation and entrance into the root canal. Timepoint: during access cavity preparation and entrance into the root canal. Method of measurement: visual analoge scale.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactProf. Shahriar Shahi

Faculty of Dentistry

shahriar_shahi@yahoo.com , shahis@tbzmed.ac.ir+98 914 314 2971

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026