Hemorrhage. Hemorrhage, not elsewhere classified
Conditions
Interventions
Intervention 1: control group: the patients were administered 1 gr of placebo dissolved in 50 millimeters of normal saline over a 15 minute period after induction of anesthesia before the start of sur
Placebo
Treatment - Drugs
control group: the patients were administered 1 gr of placebo dissolved in 50 millimeters of normal saline over a 15 minute period after induction of anesthesia before the start of surgery.
Interventional group: In the fibrinogen group the patients were administered 1 gr of fibrinogen dissolved in 50 millimeters of normal saline over a 15 minute period after induction of anesthesia befor
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: All candidates for first time elective coronary artery bypass graft surgery. Exclusion criteria: 1-Previously diagnosed hematologic or liver disease, 2-uncontrolled or insulin dependent diabetic mellitus, 3-pregnancy, 4-unstable angina, 5-serum creatinine > 130 µmol/L, 6-left ventricular ejection fraction of less than 35% prior to surgery, 7-serum fibrinogen levels of more than 3/5 g/L.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Volume of postoperative hemorrhage. Timepoint: 0,12,24h after surgery. Method of measurement: overall chest tube drainage during the first 24 hour postoperative hours and was recorded by a pre-trained intensive care unit nurse. | — |
Secondary
| Measure | Time frame |
|---|---|
| Transfusion of blood products. Timepoint: first 24 hours post surgery. Method of measurement: The amount of transfused red pack cells, fresh frozen plasma, and platelets during the first 24 hour post-surgery. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAli Movafegh
Anesthesiology Dep, Tehran University of Medical Sciences
Outcome results
None listed