Condition 1: severe depressive episode without psychotic symptoms. Condition 2: Severe depressive episode with psychotic symptoms. Severe depressive episode without psychotic symptoms Severe depressive episode with psychotic symptoms
Conditions
Interventions
Intervention 1: Six sessions of the standard bilateral ECT as well as 50 microgram liothyronin, daily, since a day before the start of the ECT until the end of sixth ECT. Intervention 2: Six sessions
Treatment - Drugs
Placebo
Six sessions of the standard bilateral ECT as well as 50 microgram liothyronin, daily, since a day before the start of the ECT until the end of sixth ECT
Six sessions of the standard bilateral ECT as well as placebo, daily, since a day before the start of the ECT until the end of sixth ECT
Sponsors
Psychiatry and Behavioral Sciences Research Center of Mazandaran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: MMD patients according to DSM IV-TR, presence of indication of ECT diagnosed by a psychiatrist, signing the informed consent Exclusion criteria: pregnancy, severe cardiac disease, thyroid dysfunction, failure to follow up
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive change. Timepoint: before treatment, after the third ECT, and after the sixth ECT. Method of measurement: wechsler test. | — |
Secondary
| Measure | Time frame |
|---|---|
| Mood change. Timepoint: before treatment, after the third ECT, and after the sixth ECT. Method of measurement: hamilton test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Seyyed Taha Yahyavi
Psychiatry and Behavioral Sciences Research Center of Mazandaran University of Medical Sciences
Outcome results
None listed