Traumatic Brain Injury. S06.1,S06.2,S06.3,S06.4,S06.5,S06.6,S06.7,S06.8,S06.9
Conditions
Interventions
Intervention 1: manitol 20% as a bolus of 1 g/kg, repeated doses can be given at 0.25 to 0.5 g/kg every six hours as needed. Intervention 2: 125 cc HSS 5% as bolus for 1 hour Q 6 hr for 3 days. Interv
Treatment - Drugs
manitol 20% as a bolus of 1 g/kg, repeated doses can be given at 0.25 to 0.5 g/kg every six hours as needed
125 cc HSS 5% as bolus for 1 hour Q 6 hr for 3 days
500 cc HSS 5% as infusion Q 24 hr for 3 days
Sponsors
Tehran University of Medical Science and Health Services
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: Age 18 - 65 years, closed traumatic brain injury, GSC score 3-12, hemodianamically stable (CVP 0.5 cc/hr, at least one reactive pupil, INR less than 1.5, Serum osmolality = 320 mOsm/kg Exclusion Criteria: pregnancy, Penetrating trauma, spinal cord injury, Serum Na> 160meq/l or less than 135meq/l, Scr>1.5 mg/dl, ARF during the treatment
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| S100B. Timepoint: baseline and after 1, 2, 3 days. Method of measurement: blood sampling and ELISA kit.;Reactive oxygen species. Timepoint: baseline and after 1, 2, 3 days. Method of measurement: blood sampling and ELISA kit.;Total antioxidant power. Timepoint: baseline and after 1, 2, 3 days. Method of measurement: blood sampling and ELISA kit. | — |
Secondary
| Measure | Time frame |
|---|---|
| APACHE II score. Timepoint: baseline and every 6 hours for 4 days. Method of measurement: international table.;SOFA score. Timepoint: baseline and after 1, 2, 3 days. Method of measurement: international table.;Glasgow Coma Scale. Timepoint: baseline and after 1, 2, 3 days. Method of measurement: international table.;Heart rate. Timepoint: baseline and after 1, 2, 3 days. Method of measurement: mmhg.;Respiratory rate. Timepoint: baseline and after 1, 2, 3 days. Method of measurement: monitoring device in ICU.;Pottasium. Timepoint: baseline and after 1, 2, 3 days. Method of measurement: laboratory.;Serum creatinine. Timepoint: baseline and after 1, 2, 3 days. Method of measurement: laboratory.;Temperature. Timepoint: baseline and after 1, 2, 3 days. Method of measurement: thermometer.;Central vein pressure. Timepoint: baseline and after 1, 2, 3 days. Method of measurement: central vein pressure ruler.;Mean arterial pressure. Timepoint: baseline and after 1, 2, 3 days. Method of measurement: (SPB+2DBP)/3.;Platelet count. Timepoint: baseline and after 1, 2, 3 days. Method of measurement: laboratory.;Hemoglobin. Timepoint: baseline and after 1, 2, 3 days. Method of measurement: laboratory.;White blood cell (WBC) count. Timepoint: baseline and after 1, 2, 3 days. Method of measurement: laboratory.;Serum sodium. Timepoint: baseline and every 6 hour for 4 days. Method of measurement: laboratory. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Narjes Hendoiee
Department of clinical pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences and Heal
Outcome results
None listed