Effect of metoclopramide on postoperative nausea and vomiting

comparison study of metoclopramide and ketamine on postoperative nausea and vomiting

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201011054819N1

Enrollment

Registered

2010-12-22

Start date

2008-04-20

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postopertive pain.

Interventions

Intervention 1: Metoclopramide, 10 mg, intravenously, 30 minutes before induction of anesthesia. Intervention 2: Ketamine, 0.3 mg/kg, intravenously, 30 minutes before induction of anesthesia.

Treatment - Drugs

Metoclopramide, 10 mg, intravenously, 30 minutes before induction of anesthesia

Ketamine, 0.3 mg/kg, intravenously, 30 minutes before induction of anesthesia

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 18-65 years old male and female patients with ASA1-2, no hypersensitivity to Ketamine or Metochlopramide who are candidates for elective laparotomy surgery under general anesthesia Exclusion criteria: severe bleeding during anesthesia and need to blood transfusion during surgery

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Postoperative pain. Timepoint: At 30th and 60th minutes at the recovery room and 2, 4, 6, and 24 hours postoperatively. Method of measurement: visual anlogue scale (VAS).	—

Secondary

Measure	Time frame
Recovery stay time. Timepoint: end of recovery stay. Method of measurement: in minutes.;Amounts of opoid consumption. Timepoint: At the recovery room and over 24 hours postoperatively. Method of measurement: in mg.;Amounts of ondansetron consumption. Timepoint: Over 24 hours postoperatively. Method of measurement: in mg.;Postoperative nausea and vomiting. Timepoint: At the recovery room and 6, 12, and 24 hours postoperatively. Method of measurement: observation and VAS.;Irritability. Timepoint: at recovery room. Method of measurement: observation.;Psychologic problems. Timepoint: at recovery. Method of measurement: observation.	—

Measure

Time frame

Recovery stay time. Timepoint: end of recovery stay. Method of measurement: in minutes.;Amounts of opoid consumption. Timepoint: At the recovery room and over 24 hours postoperatively. Method of measurement: in mg.;Amounts of ondansetron consumption. Timepoint: Over 24 hours postoperatively. Method of measurement: in mg.;Postoperative nausea and vomiting. Timepoint: At the recovery room and 6, 12, and 24 hours postoperatively. Method of measurement: observation and VAS.;Irritability. Timepoint: at recovery room. Method of measurement: observation.;Psychologic problems. Timepoint: at recovery. Method of measurement: observation.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactJamshid Salehi

Isfahan University of Medical Sciences

m_heidari@med.mui.ac.ir+98 31 1668 5555

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026