Classic migraine. Classic(with aura)migraine
Conditions
Interventions
Intervention 1: Topiramate tablet(25 mg)twice a day orally for 12 weeks. Intervention 2: Sodium valproate tablet(200 mg)twice a day orally for 12 weeks.
Treatment - Drugs
Topiramate tablet(25 mg)twice a day orally for 12 weeks
Sodium valproate tablet(200 mg)twice a day orally for 12 weeks
Sponsors
Vice-chancellor for research, Ahvaz Jondishapour University of Medical Sciences and Health Services
Eligibility
Sex/Gender
Female
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: Patient’s age between 20 and 45 years, discontinuation of other prophylactic drugs one month prior to study, interval between attacks more than 48 hours Exclusion criteria: pregnancy and breast feeding, non-migraine headaches, overuse of medications in migraine attacks (consumption of NSAID, Ergots & Triptans more than 8 days a month), substance and alcohol abuse, illiteracy of patients and their family (unable to fill diaries) minimal age:20 maximal age:45 sex:female
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Headache severity. Timepoint: On each episode of headache. Method of measurement: The patient registers the severity of her headaches in daily notes according to VAS(FROM 1 TO 10)and these notes are registered by physician monthly.;Headache duration. Timepoint: On each headache episode. Method of measurement: The patient registers the duration of each headache episode and these data are registered by the physician monthly.;Headaches frequencies. Timepoint: Monthly. Method of measurement: According to patient's notes.;Analgesic consumption rate. Timepoint: Monthly. Method of measurement: According to patient's notes. | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical side effects. Timepoint: Every 4 weeks. Method of measurement: According to patients daily notes.;Blood cell count & liver function test changes. Timepoint: Before and at the end of treatment course. Method of measurement: Lab tests. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr.Alireza Yarahmadi
Ahvaz Golestan Hospital
Outcome results
None listed