Coenzyme Q10 and aerobic exercise effect on oxidative damages

Effect of aerobic exercise and short-term coenzyme Q10 supplementation on on serum total antioxidant capacity, malondiadehyde and creatine kinase in male non-athletes.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201011024663N3

Enrollment

Registered

2011-12-01

Start date

2010-05-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Exercise-induced Oxidative damages. Drug or medicament, unspecified

Interventions

Intervention 1: After 14-days supplementation, Placebo group (2.5 mg/kg/day Dextrose), will participate in an aerobic exercise protocol with 75% VO2max on the treadmill for 30 minutes. Intervention 2:

Placebo

Treatment - Drugs

After 14-days supplementation, Placebo group (2.5 mg/kg/day Dextrose), will participate in an aerobic exercise protocol with 75% VO2max on the treadmill for 30 minutes.

After 14-days supplementation, supplement group (2.5 mg/kg/day Coenzyme Q10), will participate in an aerobic exercise protocol with 75% VO2max on the treadmill for 30 minutes.

Eligibility

Sex/Gender

Male

Age

22 Years to 28 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Healthy male non-athletes, age 22-28 years, without any exercise training and inflammatory or oxidative supplement ingestion during 6 months prior to the study. Exclusion criteria: chronic diseases, injuries, aerobic power higher than 55ml/kg/min, fat percent lower than 10%.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Serum Total antioxidant capacity (TAC). Timepoint: 14 days after the initiation of the intervention. Method of measurement: by Frap Method.;Serum Malondialdehyde. Timepoint: 14 days after the initiation of the intervention. Method of measurement: by thiobarbituric acid reactive substance (TBARS) and spectrophotometer.;Creatine Kinase Activity. Timepoint: 14 days after the initiation of the intervention. Method of measurement: by automatic analyzer and spectrophotometer.	—

Measure

Time frame

Serum Total antioxidant capacity (TAC). Timepoint: 14 days after the initiation of the intervention. Method of measurement: by Frap Method.;Serum Malondialdehyde. Timepoint: 14 days after the initiation of the intervention. Method of measurement: by thiobarbituric acid reactive substance (TBARS) and spectrophotometer.;Creatine Kinase Activity. Timepoint: 14 days after the initiation of the intervention. Method of measurement: by automatic analyzer and spectrophotometer.

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Secondary

Measure	Time frame
Plasma Lactate. Timepoint: 14 days after the initiation of the intervention. Method of measurement: by automatic analyzer .;Peripheral blood leukocytes counts. Timepoint: 14 days after the initiation of the intervention. Method of measurement: It will determine by automatic analyzer.;Maximal Oxygen Consumption. Timepoint: 14 days after the initiation of the intervention. Method of measurement: by Bruce treadmill protocol.	—

Measure

Time frame

Plasma Lactate. Timepoint: 14 days after the initiation of the intervention. Method of measurement: by automatic analyzer .;Peripheral blood leukocytes counts. Timepoint: 14 days after the initiation of the intervention. Method of measurement: It will determine by automatic analyzer.;Maximal Oxygen Consumption. Timepoint: 14 days after the initiation of the intervention. Method of measurement: by Bruce treadmill protocol.

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Countries

Iran (Islamic Republic of)

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026