Effect of celecoxib on post operative pain

Effect of preemptive celecoxib on pain score reduction and opioid consumption following lower extremity Surgery

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201010284947N2

Enrollment

Registered

2010-11-22

Start date

2010-04-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

fracture of leg. Broken leg NOS

Interventions

Intervention 1: Celecoxib 200mg, orally, 2 hours before operation. Intervention 2: Placebo, orally, 2 hours before operation.

Treatment - Drugs

Placebo

Celecoxib 200mg, orally, 2 hours before operation

Placebo, orally, 2 hours before operation

Eligibility

Sex/Gender

All

Age

20 Years to 50 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: age between 20 and 50 years old, ASA class 1 or 2 Exclusion criteria: weight less than 40 or higher than 100 kg, opium addiction, history of MI, peptic ulcer, renal failure, Aspirin allergy, lithium usage, psychiatric disorder

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Pain intensity. Timepoint: in 2 and 6 and 12 and 24 houres after operation. Method of measurement: VAS score.	—

Secondary

Measure	Time frame
Opioid consumption. Timepoint: 24 hr after operation. Method of measurement: Medical records.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Mahdi Dadras

Zahedan University of Medical Sciences and Health Services

dadras@zaums.ac.ir+98 54 1341 1260

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026