The Effect of desmopressin administration on intraoperative blood loss of sinus surgery

The Effect of nasal spray of desmopressin administration on intraoperative blood loss and quality of the surgical field during functional endoscopic sinus surgery in patients with chronic rhino sinusitis

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20101026005026N9

Enrollment

Registered

2018-05-08

Start date

2017-12-22

Completion date

Unknown

Last updated

2018-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bleeding during endoscopic surgery of sinuses (FESS). Chronic sinusitis

Interventions

Intervention 1: One puff Desmopressin nasal spray (10 µg) in either nostril before anesthesia. Intervention 2: One puff nasal spray of normal saline in either nostril before anesthesia.

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: All patients must be 18–65 years old, who it is their first-time candidates for two-side FESS

Exclusion criteria

Exclusion criteria: Patients with a history of bleeding disorders or taking medications that may affect surgical homeostasis; Poorly controlled hypertension or cerebrovascular disease; A history of significant coronary artery disease or arrhythmia Secondary surgery Pregnancy A compromised renal or hepatic function; and

Design outcomes

Primary

Measure	Time frame
Intraoperative blood loss. Timepoint: Every 15 minuets from the begining of anesthesia until maximum 90 minutes. Method of measurement: Final intraoperative blood loss was confirmed at the end of each procedure by accounting for loss of blood and irrigation fluid into the suction canister, and nasopharyngeal packing (measured weight of packing on the electronic scale).;Quality of the surgical field during functional endoscopic sinus surgery. Timepoint: End of surgery. Method of measurement: A scoring scale adapted from Boezaart and van der merew.	—

Measure

Time frame

Intraoperative blood loss. Timepoint: Every 15 minuets from the begining of anesthesia until maximum 90 minutes. Method of measurement: Final intraoperative blood loss was confirmed at the end of each procedure by accounting for loss of blood and irrigation fluid into the suction canister, and nasopharyngeal packing (measured weight of packing on the electronic scale).;Quality of the surgical field during functional endoscopic sinus surgery. Timepoint: End of surgery. Method of measurement: A scoring scale adapted from Boezaart and van der merew.

—

Secondary

Measure	Time frame
Bleeding after the surgery. Timepoint: Until 4 days after surgery. Method of measurement: Questionnaire.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMasood Mohseni

Iran University of Medical Sciences

masood.mohseni@gmail.com+98 21 6435 2326

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026