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The effect of Letrozole on Clomiphene resistance

Letrozole induction of ovulation in infertile women with Clomiphene resistance

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT201010174868N2
Enrollment
30
Registered
2011-01-31
Start date
2009-03-21
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Female infertility. Female infertility associated with anovulation

Interventions

Oral letrozol in doses of 2/5, 5and 7.5 mg (depending on patient response
overall 72 cycles) higher dose was administered to the patients who did not have mature follicle with lower dose..
Treatment - Drugs
overall 72 cycles) higher dose was administered to the patients who did not have mature follicle with lower dose.

Sponsors

Vice Chancellor for Research of Qazvin University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 37 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: age 18-39, infertility more than 2 years, normal Thyroid Stimulating Hormone (TSH), spermogram and prolactin and normal Follicle-stimulating hormone (FSH) in beginning of follicular phase. Exclusion criteria: history of pelvic surgery, presence of adhesions in laparoscopy or hystrosalpingography and presence of any infertility factors except anovulation.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Presence and number of dominant follicles. Timepoint: 4 days after the end of treatment. Method of measurement: vaginal sonography.

Secondary

MeasureTime frame
Pregnancy. Timepoint: 26 days after treatment. Method of measurement: presence of gestational sac in vaginal sonography.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Khadijeh Elmizadeh

Qazvin University of Medical Sciences

khelmizadeh@qums.ac.ir+98 28 1223 6380

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026