Diabetes Mellitus. Non-insulin-dependent diabetes mellitus, type II
Conditions
Interventions
Intervention 1: Control group: placebo as similar tablets 3 times daily oral for 3 months. Intervention 2: Intervention group: pentoxifylline tablet 400 mg 3 times daily orally for 3 months.
Placebo
Treatment - Drugs
Control group: placebo as similar tablets 3 times daily oral for 3 months
Intervention group: pentoxifylline tablet 400 mg 3 times daily orally for 3 months
Sponsors
Babol University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria: diabetics type 2 with proteinuria more than 500 mg /d under treatment with ACEI for at least 3 months Exclusion criteria: diabetics type 1, creatinin more than 1.5 mg/dl, systolic blood pressure more than 140 mmHg, Patients on hemodialysis, presence of fever, acute respiratory distress, or acute heart failure, non- diabetic proteinuric glomerulopathies, obstructive urinary stones, confirmed hypersensitivity to caffeine, theophylline or pentoxifylline, recent brain or retinal hemorrhage, recent 3 months use of thiazolidinediones
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proteinuria. Timepoint: before and after intervention. Method of measurement: 24 hours urinary protein measurment. | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum creatinine. Timepoint: Before and after the intervention. Method of measurement: serum cratinine measurement by jaffe method. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Farshid Oliaee
Babol University of Medical Sciences
Outcome results
None listed