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Effect of combined topical solution 2% salicylic acid and erythromycin 4% with erythromycin 4% topical solution in the treatment of mild to moderate acne vulgaris

Comparison???? of efficacy of topical combination solution of salicylic acid 2% and erythromycin 4% with topical solution of erythromycin 4% alone in mild to moderate acne vulgaris treatment; double-blinded randomized clinical trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT201010094269N3
Enrollment
50
Registered
2011-10-19
Start date
2010-10-23
Completion date
Unknown
Last updated
2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mild to modrate acne vulgaris. Acne vulgaris

Interventions

Intervention 1: Intervention group: combination of erythromycin 4 g and salicylic acid in 10 cc propylene glycol and alcohol 70 degrees to the volume of the overall 100 cc will apply to the face with
Treatment - Drugs
Intervention group: combination of erythromycin 4 g and salicylic acid in 10 cc propylene glycol and alcohol 70 degrees to the volume of the overall 100 cc will apply to the face with cotton applica
Control group: combination of erythromycin 4 g in 10 cc propylene glycol and alcohol 70 degrees to the volume of the overall 100 cc will be apply to the face with cotton applicator twice aday for 3

Sponsors

Deputy of Tabriz University of Medical Sciences and Health Services
Lead Sponsor

Eligibility

Sex/Gender
All
Age
11 Years to 30 Years

Inclusion criteria

Inclusion criteria: Exclusion criteria:patients who are using topical or systemic steroids ; patients who are using contraceptive pills (anti-androgen); patients who are used topical or oral anti-acne medications, during the previous month, even include natural and UV light and Herbal and traditional acne treatments; if there are other face dermatosis and other systemic acne accelerator diseases such as Cushing's syndrome, PCO,adrenal hyperplasia, acquired and innate immun deficiency, steroid acne and acneiform lesions and ....; patient's dissatisfaction ;if there are more than 20 inflammatory lesions (papules and pustules) and three nodules or cysts on one side of the face ; patients with acne excoree ;age under 11 y/o andover 30 y/o ;if there is an inflammatory disease,except acne, on the face such as contact dermatitis, allergic or seborrheic dermatitis and... Inclusion criteria:patients with mild to moderate acne in age range 11-30 years old ; patients who have maximum 20 inflammatory lesions (papules &pustule) on one side of the face and have not more than three nodules or cysts on the same side of the face; lack of other face dermatosis such as contact dermatitis, allergic or seborrheic dermatitis and ...; having patient's satisfaction ; lack of other systemic acne accelerator diseases such as Cushing's syndrome, PCO, adrenal hyperplasia, acquired and innate immun deficiency, steroid acne and acneiform lesions and.... ; patients who are not used of oral or topical anti-acne medications, during the previous month, even include natural and UV light, herbal and traditional acne treatments.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
Acne severity index. Timepoint: Every15 days. Method of measurement: History, physical examination, counting and statistical evaluation.

Secondary

MeasureTime frame
Age. Timepoint: Every 15 days. Method of measurement: History.;Gender. Timepoint: Every 15 days. Method of measurement: History.;Comedon. Timepoint: Every 15 days. Method of measurement: Physical examination and counting.;Papule. Timepoint: Every 15 days. Method of measurement: Physical examination and counting.;Pustule. Timepoint: Every 15 days. Method of measurement: Physical examination and counting.;Total numbers of lesions. Timepoint: Every 15 days. Method of measurement: Physical examination and counting.;Patient's satisfaction. Timepoint: Every 15 days. Method of measurement: History.;Side efect of treatment. Timepoint: Every 15 days. Method of measurement: History and physical examination.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarideh Golfroushan

Deputy of Tabriz University of Medical Sciences and Health Services

Dr_fgolfroushan@yahoo.com & golfroushanf@tbzmed.ac.ir+98 41 1540 6612

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026