Recurrent depressive disorder. Recurrent depressive disorder
Conditions
Interventions
Intervention 1: Control group: receiving coconut oil 1000 mg/day (2 oral capsules) for 12 weeks. Intervention 2: First intervention group: receiving eicosapentaenoic acid 1000 mg/day (2 oral capsules)
Placebo
Treatment - Drugs
Control group: receiving coconut oil 1000 mg/day (2 oral capsules) for 12 weeks
First intervention group: receiving eicosapentaenoic acid 1000 mg/day (2 oral capsules) for 12 weeks
Second intervention group: receiving docosahexaenoic acid 930 mg/day (2 oral capsules) for 12 weeks
Sponsors
Research Accessory of Shahid Sadughi University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: ages between 18-75 years; a Beck Depression Inventory II score of 10-28; a Hamilton Rating Scale for Depression score of 8-18; no changes in doses or types of antidepressant medications within 4 weeks prior to the study entry; diagnose of mild to moderate depression with structured clinical interview by a psychiatrist according to DSM-IV-TR criteria Exclusion criteria: diagnosis of any co-morbid mental disorder other than depression, serious suicidal or homicidal thoughts; use of fish oil or omega, supplements within the last 6 months or having taken more than 3 servings per weeks of fish; any changes in doses or types of current antidepressant medications within study period or use of psychotropics, anticonvulsants, mood stabilizers, and anticoagulants; cupping or blood coagulation disorders, gastrointestinal absorption disorders, and eating disorders; allergy to sea foods or study drugs, and history of multiple adverse drug reactions; history of electroconvulsive therapy or severe medical disorders that may lead in depression including cardiovascular, hepatic, renal, respiratory, and endocrine diseases; smoking and drug or alcohol abuse; pregnancy or breastfeeding; serious adverse effects and incompliance to study protocol
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Severity of depression. Timepoint: Weeks 0, 6, and 12. Method of measurement: Hamilton Rating Scale for Depression. | — |
Secondary
| Measure | Time frame |
|---|---|
| Remission. Timepoint: Week 12. Method of measurement: Hamilton Rating Scale for Depression. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSeyede Elahe Shariaty Bafghi
Department of Nutrition, School of Health, Shahid Sadughi University of Medical Sciences
Outcome results
None listed