The effect of red grape seed extract on human semen parameters

Evaluation of the effect of red grape seed extract on idiopathic infertile male patients’ spermogram at Royan infertility center in 2010

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

IRCT

Registry ID

IRCT201010034861N1

Enrollment

Registered

2010-10-25

Start date

2010-05-22

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Male Infertility. Male Infertility

Interventions

Intervention 1: Intervention: Red Grape Seed Extract, Capsule 300mg, Twice/day, for 3 months. Intervention 2: Control: Placebo, Capsule 300mg, Twice/day, for 3 months.

Treatment - Drugs

Placebo

Intervention: Red Grape Seed Extract, Capsule 300mg, Twice/day, for 3 months

Control: Placebo, Capsule 300mg, Twice/day, for 3 months

Eligibility

Sex/Gender

Male

Age

20 Years to 45 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: Oligozoospermia with sperm count 5-20 million/ml and astenozoospermia with progressive motility less than 40% Exclusion criteria: Explained infertility (e.g. hormonal disorders, epididimis canal obstruction, epididimorchitis,...) smoking, drug or alcohol addiction, diabetes, renal disorders (creatinine more than 2.0 times), chronic liver diseases (transaminase more than twice as much normal), varicocele, infectious diseases indicated with fever and leukocytosis, sexual arousing-drugs consumption

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Sperm Motility. Timepoint: before intervention and a week after intervention. Method of measurement: Motility velocity and percentage.;ROS (Reactive Oxygen Species) levels. Timepoint: before intervention and a week after intervention. Method of measurement: Concentration assay by chemiluminesence method.;Sperm Concentration. Timepoint: before intervention and a week after intervention. Method of measurement: Counting the sperms.	—

Measure

Time frame

Sperm Motility. Timepoint: before intervention and a week after intervention. Method of measurement: Motility velocity and percentage.;ROS (Reactive Oxygen Species) levels. Timepoint: before intervention and a week after intervention. Method of measurement: Concentration assay by chemiluminesence method.;Sperm Concentration. Timepoint: before intervention and a week after intervention. Method of measurement: Counting the sperms.

—

Secondary

Measure	Time frame
FSH level. Timepoint: Befor intervention and a week after intervention. Method of measurement: ELISA.;LH level. Timepoint: Befor intervention and a week after intervention. Method of measurement: ELISA.;Testosterone level. Timepoint: Befor intervention and a week after intervention. Method of measurement: ELISA.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactReza Salman Yazdi

Royan Institute

r_salman_yazdi@yahoo.com+98 21 2230 6478

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026