Pregnancy with abortive outcome. Pregnancy with abortive outcome
Conditions
Interventions
Intervention 1: 50mg/m2 methotrexate IM, with single dose oral placebo (same as mifepristone). Intervention 2: single dose of methorexate IM + 600mg mifepoistone oraly.
Placebo
Treatment - Other
50mg/m2 methotrexate IM, with single dose oral placebo (same as mifepristone)
single dose of methorexate IM + 600mg mifepoistone oraly
Sponsors
Kermanshah University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
15 Years to 45 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: stable Hemodynamic state, Without Bleeding or hemo-peritoneum, un ruptured ectopic pregnancy, ectopic pregnancy mass without FHR, ectopic pregnancy mass smaller than 4cm, BHCG less than 1500 mlu/ml, no contradiction of use of methotrexate or mifepristone Exclusion criteria: decrease in serum BHCG, BHCG less than1500 mlu/ml and depletion after 48 h, history of liver and renal diseases, hematologic or others disorders such as: glaucoma, porphyria, thalassemia, ulcerative colitis, heart diseases, psychological diseases, corticosteroid use more than 6 months, prior sensitivity to methotrexate or mifepristone
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ectopic Pregnancy treatment. Timepoint: Days 4, 7, 11, and 14. Method of measurement: Beta hCG level. | — |
Secondary
| Measure | Time frame |
|---|---|
| Need to second methotrexate injection. Timepoint: from 4th to 7th day. Method of measurement: BhcG level.;Rate of infection. Timepoint: 4th, 7th and 11th day after intervention. Method of measurement: temperature more than 38 degree centigrade.;Surgical intervention. Timepoint: 4th day after intervention. Method of measurement: laparatomy.;Number of days required to reduce BhcG level. Timepoint: after 4th day. Method of measurement: Beta hcG level.;Hospital stay. Timepoint: from admission to discharge. Method of measurement: Number of hospitalization dayshospitalization. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactFiroozeh Veisi
Kermanshah University of Medical Sciences
Outcome results
None listed