Comparing serum homocysteine value in patients treated with folic acid and Levothyroxine with patients who receive Levothyroxine

Comparing serum homocysteine value in patients with hypothyroidism who are treated with folic acid and Levothyroxine with patients who receive Levothyroxine

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201010024849N1

Enrollment

Registered

2010-10-29

Start date

2009-03-21

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Other hypothyroidism. Other specified hypothyroidism

Interventions

Intervention 1: Levothyroxine, 50-100 mg/day as well as Folic acid, 1mg/day untill being euthyroid. Intervention 2: Levothyroxine, 50-100 mg/day untill being euthyroid.

Treatment - Drugs

Levothyroxine, 50-100 mg/day as well as Folic acid, 1mg/day untill being euthyroid

Levothyroxine, 50-100 mg/day untill being euthyroid

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria: clinical signs of hypothyroidism, TSH>10 mIU/L, normal function of kidney, not having systemic diseases. Exclusion criteria: taking drugs such as Phenobarbital, Phenytoin, Tamoxifen, Methotrexate, Theophylline, having diabetes, anemia or other systemic diseases, pregnancy, smoking

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Homosysteine level. Timepoint: after intervention. Method of measurement: micromole/litr.	—

Secondary

Measure	Time frame
Cardiovasicular complications. Timepoint: after intervention. Method of measurement: micromole/litr.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Amir Ziaee

Qazvin Uniersity of Medical Sciences

aziaee@qums.ac.ir+98 28 1336 0084

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026