coronary artery disease. Ischaemic heart diseases
Conditions
Interventions
Intervention 1: In control group 15mg/Kg Prednisolone bolus dose before operation and after sedation will be prescribed. After operation this group will be had steady infusion of normal saline (2mg/Kg
Placebo
Treatment - Drugs
In control group 15mg/Kg Prednisolone bolus dose before operation and after sedation will be prescribed. After operation this group will be had steady infusion of normal saline (2mg/Kg/d)
Intervention group will be prescribed 1mg/Kg dose of prednisolone (bolous dose) before operation and 2mg/Kg/d as infusion after that.
Sponsors
Tehran Heart Center
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria:1- age over 18. 2- written informed consent. 3- patients who are candidate for open heart surgery. Exclusion criteria: 1- recent use of systemic corticosteroid. 2- history of bacterial or fungal infection in the past two weeks. 3- history of sensitivity to corticosteroids. 4- uncontrolled diabetes mellitus. 5- history of renal failure 6- liver failure or elevated liver enzymes.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Length of stay in ICU and Intubation time. Timepoint: after transferring the patient to surgery ward. Method of measurement: questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Reduction of inflammatory mediators. Timepoint: before, 6 and 48 hours following operation. Method of measurement: Blood test. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Khosrow Barkhordari
Tehran Heart Center
Outcome results
None listed