Migraine. Migraine without aura [common migraine]
Conditions
Interventions
Intervention 1: In Intervention Group: Topiramate 2mg/kg/day in 2 divided dose ( oral ). Intervention 2: In Control Group : Propranolol 0.5-1mg/kg/day in 2 divided dose ( oral ).
Treatment - Drugs
In Intervention Group: Topiramate 2mg/kg/day in 2 divided dose ( oral )
In Control Group : Propranolol 0.5-1mg/kg/day in 2 divided dose ( oral )
Sponsors
Research Center of Mazandaran University of Medical Sciences and Health Services
Eligibility
Sex/Gender
All
Age
5 Years to 15 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria: 1- Age between 5-15 yr 2- Patient with Common Migraine IHS criteria 3- History of Headache in last 6months 4- No Drug history of Propranolol or Topiromate 5- Discontinuation of other prophylactic drugs one month prior to study 6- At least 2 episode of Migraine Headache in one month. Exclusion Criteria: 1- Contraindications of Propranolol or Topiromate in pre-existing Disease 2- Patient with Epilepsy or Movement Disorders 3- Patient who don’t follow up their Treatment 4- Appearing of drug side effects.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of Migraine Headache episode. Timepoint: Before intervention, 4 & 8 weeks after intervention. Method of measurement: Questionnarie. | — |
Secondary
| Measure | Time frame |
|---|---|
| Nausea & Vomiting. Timepoint: 4 & 8 weeks after beginning of treatment. Method of measurement: Questionnaire.;Weight loss. Timepoint: 4 & 8 weeks after beginning of treatment. Method of measurement: Questionnaire.;Drowsiness. Timepoint: 4 & 8 weeks after beginning of treatment. Method of measurement: Questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Ali Abbaskhanian
Mazandaran University of Medical Sciences and Health Services
Outcome results
None listed