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Comparing the effect of preoperative oral Gabapentin with single dose intravenous Acetaminophen on postoperative pain of knee arthroplasty

Comparing the effect of preoperative oral Gabapentin with single dose intravenous Acetaminophen on postoperative pain of knee arthroplasty

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20100920004780N12
Enrollment
90
Registered
2023-09-05
Start date
2023-10-07
Completion date
Unknown
Last updated
2023-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

knee arthroplasty surgery. Unspecified complication of internal orthopedic prosthetic device, implant and graft

Interventions

Intervention 1: Intervention group1: Infusion of 1000 milligrams of intravenous Acetaminophen during the first half-hour during surgery. Intervention 2: Intervention group: Assumption of 600 mg oral G

Sponsors

Mashhad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Physical grade I or II in ASA Lack of sensitivity to Gabapentin The absence of mental disorders Do not drink alcohol, drugs, and taking constipation, and corticosteroids and anticonvulsants on a regular basis or in the past twenty four hours No pregnancy No myasthenia grave disease Not having any kidney disease

Exclusion criteria

Exclusion criteria: The occurrence of any surgical complications during surgery Reduce or increase the average blood pressure (MAP) Heart rate is greater than 30% of the initial rate

Design outcomes

Primary

MeasureTime frame
Drug measurements. Timepoint: After intervention. Method of measurement: Morphin equivalent.

Secondary

MeasureTime frame
Pain. Timepoint: After intervention. Method of measurement: Visual analogue scale.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammad Alipour

Mashhad University of Medical Sciences

alipourm@mums.ac.ir+98 51 3852 5209

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026