Assessment the effect of Ca-Vitamin D and metformin on PCOS

The effect of Calcium-Vitamin D and Metformin on Polycystic Ovarian Syndrome

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT201009131760N9

Enrollment

Registered

2011-04-03

Start date

2010-09-23

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition 1: Polycystic ovarian syndrome. Condition 2: Female infertility associated with anovulation. Polycystic ovarian syndrome Female infertility associated with anovulation

Interventions

Intervention 1: 1- Metformin mg/d 1500 for three months. Intervention 2: 2-Calcium(1000m)+ Vitamin D 400 IU for three months. Intervention 3: 3- Calcium(1000m) + Vitamin D 400 IU + Metformin mg/d 1500

Treatment - Drugs

1- Metformin mg/d 1500 for three months

2-Calcium(1000m)+ Vitamin D 400 IU for three months

3- Calcium(1000m) + Vitamin D 400 IU + Metformin mg/d 1500 for three months

Eligibility

Sex/Gender

Female

Age

18 Years to 35 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: 1. Reproductive age range 18 to 35 years; 2. According to the Rotterdam criteria, the presences of two of the three following characteristics were required for inclusion in the study: A. oligomenorrhea/amenorrhea; B. chemical or clinical findings of hyperandrogenism; C. polycystic ovaries on transvaginal sonography. Exclusion criteria: Patients with systemic diseases such as Cushing's syndrome, hyperparathyroidism or hyperprolactinemia, androgen secreting tumors, history of abdominal/pelvic surgery, coexisting male factor infertility, or abnormal hysterosalpingography were excluded from the study.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Calcium and vitamin D. Timepoint: After three months. Method of measurement: Laboratory.;Regulate menstruation. Timepoint: After three months. Method of measurement: 35-21 day intervals with standard.;Follicular growth. Timepoint: After three months. Method of measurement: Ultrasound.	—

Secondary

Measure	Time frame
Pregnancy rate. Timepoint: After three months. Method of measurement: Ultrasound.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNargess Gholizadeh Pasha

Fatemehzahra Fertility & Reproductive Health Research Center

ngh_pa@yahoo.com+98 11 1227 4881

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026