Postoperative Endodontic Pain. Other specified disorders of teeth and supporting structures - Toothache NOS and Pulpitis: acute
Conditions
Interventions
Intervention 1: Oral suspension of ibuprofen, 600 mg, A single dose, 30 minutes before the initiation of treatment, Oral. Intervention 2: Placebo, A single dose, 30 minutes before the initiation of tr
Prevention
Placebo
Oral suspension of ibuprofen, 600 mg, A single dose, 30 minutes before the initiation of treatment, Oral
Placebo, A single dose, 30 minutes before the initiation of treatment, Oral
Ketamine hydrochloride, 0.5mg/kg, A single dose, 30 minutes before the initiation of treatment, Oral
Sponsors
School of Dentistry, Islamic Azad University Khorasgan Branch
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1. Patient elects root canal therapy for pain originating from a first or second mandibular molar. 2. The diagnosis of irreversible pulpitis is confirmed by a chief complaint of spontaneous pain and cold test application causing an elevated and lingering pain response. 3. The patient presented with American Society of Anesthesiologists (ASA) I or II medical history. 4. Patient reads and understands questionnaires. 5. Patient reports spontaneous pain above 3cm on a VAS (0-10 cm) in past 24h. 6. Patient provides informed consent. Exclusion criteria: 1. Younger than 18 yr or older than 65 yr. 2. Analgesic taken within the last 8h. 3. History of allergy to NSAIDs, ketamine or local anesthetics. 4. Current use of drugs contraindicated with NSAIDs or ketamine. 5. History of gastrointestinal (GI) disorders, renal or hepatic disease, hemorrhagic disorders, active asthma, poorly controlled diabetes mellitus, cardiovascular disease, increased ICP, intracranial mass lesions, ophthalmologic disorder or psychiatric disease. 6. The patient is pregnant or nursing. 7. Periradicular pathosis, other than a widened periodontal ligament. 8. No vital coronal pulp tissue on access. 9. Occurrence of any mistake during root canal therapy.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain intensity. Timepoint: Before and at 2, 4, 8, 12 and 24h after treatment. Method of measurement: Visual Analog Scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| The need for additional medication. Timepoint: Until 24h after treatment. Method of measurement: Questionnaire.;Time to first request for rescue analgesic. Timepoint: Until 24h after treatment. Method of measurement: Questionnaire.;The number of rescue analgesic tablets taken. Timepoint: Until 24h after treatment. Method of measurement: Questionnaire.;The incidence of side effects. Timepoint: Until 24h after treatment. Method of measurement: Questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAshkan Vakilzadeh
School of Dentistry, Isfahan University of Medical Sciences and School of Dentistry, Islamic Aza
Outcome results
None listed