major depressive disorder. Depressive episode
Conditions
Interventions
Intervention 1: Celecoxib group: 25-100mg/day Sertraline plus 100mg Celecoxib twice daily for eight weeks. Intervention 2: Control group: 25-100mg/day Sertraline plus 100mg placebo twice daily for eig
Treatment - Drugs
Placebo
Celecoxib group: 25-100mg/day Sertraline plus 100mg Celecoxib twice daily for eight weeks.
Control group: 25-100mg/day Sertraline plus 100mg placebo twice daily for eight weeks.
Sponsors
Pharmaceutical Sciences Branch of Islamic Azad university
Eligibility
Sex/Gender
Female
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1. women experiencing first episode of depression according to DSM-IV-TR and the Hamilton rating scale (17 items) score was ranged from 18 to 36. 2. None of them had previously received antidepressant treatment. Exclusion criteria: 1. History of taking antidepressant medications. 2. Other psychiatric disorders. 3. Significant suicidal ideation. 4. lactation and pregnancy. 5. Liver and kidney dysfunction and cardiovascular disorders. 6. Drug abuse.
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depression severity. Timepoint: baseline, week 4 and week 8. Method of measurement: Hamilton Depression rating scale -17 items.;Anxiety severity. Timepoint: baseline, week 4 and week 8. Method of measurement: Hamilton Anxiety rating scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| General health level. Timepoint: baseline, week 4 and week 8. Method of measurement: General health questionnair-28. | — |
Countries
Iran (Islamic Republic of)
Outcome results
None listed