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Conditions
Interventions
Intervention 1: Intervention group: In the ozone therapy group, 5 cc of ozone with a concentration of 30 micrograms per ml with 2 cc of 2% lidocaine will be injected into the joint. Ozone injections w
Sponsors
Physical Medicibe and Rehabilitaion Research Center of Tabriz
Eligibility
Sex/Gender
All
Age
45 Years to No maximum
Inclusion criteria
Inclusion criteria: Moderate Knee Osteoarthritis (grade two or three based Radiographic classification (Kellegren and Lawrence) Existence of symptoms in favor of Knee Osteoarthritis for at least 3 months Minimum score of 3 in the criterion (VAS) Absence of Inflammatory Rheumatic diseases 45 years old and older Satisfaction of patients participating in the study Failure to respond to Conservative drug treatments and physiotherapy lasted for 6 months
Exclusion criteria
Exclusion criteria: Severe Osteoarthritis (grade 4 candidates for joint replacement surgery) Rheumatic disease Clearly Visible deformity of the knee Ankylosis Contraindications to Ozone include: Hyperthyroidism , Thrombocytopenia ,Pregnancy , Recent heart attack history ,G6PD Deficiency Definitive and partial Contraindications to Steroid injection include: Bacteremia, Sepsis, Intra articular or pre uricular infection, History of post injection Allergy, Intra articular or Osteochondral fracture at the injection site, Severe Joint destruction in Injection site , Artificial joint , Uncontrolled Coagulation disorders Specific skin lesion at the injection site
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The amount af Reduce in pain after injection. Timepoint: Immediately before injection and 1 month after injection and 6 months after injection. Method of measurement: Western Ontario and McMaster Universities Arthritis Index (WOMAC)questionare. | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement of function of Knee. Timepoint: Immediately before injection and one and six months after injection. Method of measurement: Western Ontario and McMaster Universities Arthritis Index (WOMAC)questionare. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Bina Eftekharsadat
Tabriz University of Medical Sciences
Outcome results
None listed