Condition 1: patients with low ejection fraction, undergoing isolated on pump coronary artery bypass surgery (CABG). Condition 2: Ischaemic heart diseases. - Ischaemic heart diseases
Conditions
Interventions
Intervention 1: The GIK group received GIK solution (500 ml DW10% + 40U regular insulin+40 mEq KCl and 2gr MgSO4) at a rate of 50 ml/h for 10 hours preoperatively until the removal of aortic cross cla
Treatment - Drugs
The GIK group received GIK solution (500 ml DW10% + 40U regular insulin+40 mEq KCl and 2gr MgSO4) at a rate of 50 ml/h for 10 hours preoperatively until the removal of aortic cross clamp
The control group received half saline solution as placebo with an equivalent infusion rate during the same duration.
Sponsors
Research Deputy, School of Medicine, Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: inclusion criteria: elective first-time CABG with cardiopulmonary bypass (CPB), LVEF=40%; as assessed by preoperative echocardiography) and patient consent for entering the study exclusion criteria: diabetics, patients who required concomitant valvular heart surgery, preoperative use of cardiovascular support (inotropes and/or an intraaortic balloon pump), or a serum creatinine level of >200 µmol/L were considered as exclusion criteria
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Measurement of serum NT-proBNP levels. Timepoint: before the initiation of the solutions, at the time of anesthesia induction and 24h after surgery. Method of measurement: Roche Elecsys assay. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMahnoosh Foroughi
Research and Developement Center
Outcome results
None listed