The effect of vitamin D in the prevention of MS disease in first degree relatives of MS patients.

The effect of vitamin D supplementation on the gene expression of See-Saw model interleukins in the first degree of apparently healthy relatives of multiple sclerosis patients.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT201008163655N2

Enrollment

Registered

2016-11-06

Start date

2017-02-19

Completion date

Unknown

Last updated

2018-02-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple Sclerosis. Multiple sclerosis

Interventions

Intervention 1: treatment group : vitamin D supplementation, 50000 IU/week, for 8 weeks. Intervention 2: control group : placebo of starch or Maltodextrose,for 8 weeks.

Placebo

treatment group : vitamin D supplementation, 50000 IU/week, for 8 weeks.

control group : placebo of starch or Maltodextrose,for 8 weeks.

Eligibility

Sex/Gender

All

Age

25 Years to 35 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria :could donate blood samples; tend to take part in study and fill FFQ and food record forms; having 20-40 years old. Exclusion criteria: having ma labsorption; consumption of medicine that interact with Vitamin D absorption; catching chronic and immune system diseases; consumption of Ca & Vitamin D supplementation; gestation and lactation.

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Interleukin 10. Timepoint: twice : before and after 2 months. Method of measurement: by Real Time-PCR.;Interleukin 17A. Timepoint: twice : before and after 2 months. Method of measurement: by Real Time-PCR.;Interleukin 6. Timepoint: twice : before and after 2 months. Method of measurement: by Real Time-PCR.;25- hydroxy vitamin D level. Timepoint: twice : before and after 2 months. Method of measurement: by Electro Chemiluminescence.	—

Measure

Time frame

Interleukin 10. Timepoint: twice : before and after 2 months. Method of measurement: by Real Time-PCR.;Interleukin 17A. Timepoint: twice : before and after 2 months. Method of measurement: by Real Time-PCR.;Interleukin 6. Timepoint: twice : before and after 2 months. Method of measurement: by Real Time-PCR.;25- hydroxy vitamin D level. Timepoint: twice : before and after 2 months. Method of measurement: by Electro Chemiluminescence.

—

Secondary

Measure	Time frame
Serum creatinine. Timepoint: twice : before and after 2 months. Method of measurement: by Enzymatic Method.;Weight. Timepoint: once : before intervention. Method of measurement: by digital scales with 0.1 Kg sensitivity.;Body Mass Index ( BMI ). Timepoint: once : before intervention. Method of measurement: calculated with Quetlet's formula(weight(kg)/(height*height(m))).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr.S Rafie Aref Hosseini

Tabriz University of Medical Sciences,Faculty of Nutrition and Food Sciences

srarefhosseini@gmail.com+98 41333575813

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026