Effect of Melatonin on prevention of delirium

Effect of Melatonin on the incidence of delirium in patients admitted to the intensive care unit: A randomized controlled clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20100816004578N8

Enrollment

140

Registered

2020-05-12

Start date

2019-08-23

Completion date

Unknown

Last updated

2020-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Delirium. Delirium due to known physiological condition

Interventions

Intervention 1: Intervention group: Melatonin 3 mg tablet, orally at 9 p.m, every night for one week or till discharge from ICU + Receiving standard treatment of the intensive care unit. Intervention

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Ages 17 to 70 years Having the power of communication RASS score equal to or greater than -3 Hospitalized for at least seven days in ICU ward

Exclusion criteria

Exclusion criteria: Vision and hearing problems History of mental disorders such as psychosis and mental retardation History of antipsychotic medication use

Design outcomes

Primary

Measure	Time frame
Delirium incidence. Timepoint: Daily. Method of measurement: Confusion Assessment Method for the ICU (CAM-ICU); Intensive Care Delirium Screening Checklist (ICDSC).	—

Secondary

Measure	Time frame
Number of admission days. Timepoint: after discharge from hospital. Method of measurement: patient's records.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarshid Rahimi-Bashar

Hamedan University of Medical Sciences

fr_rahimibashar@yahoo.com+98 81 3264 0047

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026