Camparison Effects of Autologous Conditioned Serum, platelet rich plasma and Prolotherapy in treatment of Knee osteoarthritis

Effects of Orthokine( Autologous Conditioned Serum), platelet rich plasma(PRP) and Prolotherapy on pain and function of patient with Knee osteoarthritis: A Randomized Clinical Trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20100720004422N6

Enrollment

Registered

2019-08-07

Start date

2019-01-30

Completion date

Unknown

Last updated

2020-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee osteoartritis. Osteoarthritis of knee

Interventions

Intervention 1: Control group: intra articular knee injection of dextrose prolotherapy ( mixture of 2ml dextrose 50% and 2 ml sterile water and 1ml Lidocaine )will be done weekly for 3 weeks under u

Eligibility

Sex/Gender

All

Age

40 Years to 75 Years

Inclusion criteria

Inclusion criteria: Age between 40-75 Grade I-II-III of OA (Kellgren-Lawrence) Pain severity >4 in a 10-numbered linear scale Pain in more than 3 months

Exclusion criteria

Exclusion criteria: Grade IV of OA Multifactorial Knee Pain Lower limb Deformity

Design outcomes

Primary

Measure	Time frame
Functional condition. Timepoint: At the beginning of the study(before the intervention) ? one and six months after treatment. Method of measurement: Western Ontario and McMaster (WOMAC) questionair.;Pain severity. Timepoint: Visual Analogue Scale (VAS) and Western Ontario and McMaster (WOMAC) questionnaire. Method of measurement: At the beginning of the study(before the intervention) and one and six months after treatment.	—

Measure

Time frame

Functional condition. Timepoint: At the beginning of the study(before the intervention) ? one and six months after treatment. Method of measurement: Western Ontario and McMaster (WOMAC) questionair.;Pain severity. Timepoint: Visual Analogue Scale (VAS) and Western Ontario and McMaster (WOMAC) questionnaire. Method of measurement: At the beginning of the study(before the intervention) and one and six months after treatment.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAlireza Pishgahi

Tabriz University of Medical Sciences

alirezapishgahi1364@gmail.com+98 914 218 3786

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026