Condition 1: Polycystic ovary syndrome. Condition 2: Women Infertility. Polycystic ovarian syndrome Female infertility
Conditions
Interventions
Intervention 1: Intervention group: Turmeric tablet containing 450 mg of turmeric rhizome powder and 50 mg of turmeric extract, which is standardized by Dineh Pharmaceutical Company with drug registra
Sponsors
Iran University of Medical Sciences
Dineh Pharmaceutical Company of Iran
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: Women undergoing IVF infertility treatment Iranian origin Ages 18-40 years married Body mass branch below 30 kg/m2
Exclusion criteria
Exclusion criteria: 1) Consumption of food and pharmaceutical supplements 2) Adhering to a special diet such as vegetarianism 3) Women with a history of infertility with simultaneous diagnosis of polycystic ovary syndrome and endometriosis 4) Hepatic and biliary disorders 5) under treatment with anticoagulant drugs 6) Active gastric ulcer 7) Having a history of allergy to turmeric or its products 8) Slimming diets 9) Athletes or special sports
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| "Changes in inflammatory indices in women with polycystic ovary syndrome". Timepoint: 6 weeks after starting to take turmeric tablets. Method of measurement: Inflammatory indices in this study mean the measurement of C-reactive protein (in milligrams per liter), interleukin-6 (ELISA method) and the ratio of neutrophils to lymphocytes in the serum and follicular fluid of patients. IL-6: Interleukin 6 Human Platinum ELISA kit with ELISA method; It can be measured with a sensitivity of 0.92 pg/m and with a normal range of results: 1-100 pg/ml. CRP: Bionik CRP biochemistry kit made in Iran with photometric method and normal range of results: values up to 6 mg/L can be measured. Neutrophil to lymphocyte ratio: Sysmex model N-21KX machine is used for cell counting and to determine the percentage of neutrophils and lymphocytes, visual method or light microscope and Giemsa staining are used.;And "Changes in oxidative stress indices in women with polycystic ovary syndrome". Timepoint: 6 weeks after starting to take turmeric tablets. Method of measurement: Oxidative stress indicators: Oxidative stress indicators in this research mean the measurement of malondialdehyde MDA (in micromolar per liter), total antioxidant capacity TAC and reactive oxygen radical ROS (milliunits per milliliter) in serum and follicular fluid of patients . MDA: It is measured using a 96-piece Well-plate kit made in Iran, Kia Biot Company, with a fluorimetric method that has a normal dynamic range: 20-100 µm. TAC: It is measured using a 96-piece Clean photometric plate well kit made in Iran, Kia Zeet company, with the Kuprak method, which has a dynamic range of 40-400 nmol/ml. ROS: It is measured by flow cytometry and fluorimetry using a kit of 96 Well Ste | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactLeila Amini
Iran University of Medical Sciences
Outcome results
None listed