Male idiopathic infertility. Male infertility
Conditions
Interventions
Intervention 1: Intervention group: Intervention group 1: HCG ampoule at a dose of 5000 units twice weekly and letrozole tablet 2.5 mg daily for 3 months. Intervention 2: Intervention group: Intervent
Sponsors
Tabriz University of Medical Sciences
Eligibility
Sex/Gender
Male
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: Obese men with a body mass index greater than 30 Idiopathic infertility Age 20 to 45 years Men with informed consent
Exclusion criteria
Exclusion criteria: Men with a history of genital surgery Men with a history of infectious disease in the genital system Men with symptoms of urinary or genital infection Men with a history of suspected contact or urethritis symptoms Men with spermatogenesis-damaging drugs such as Sulfasalazine Men with history of tobacco and alcohol or drugs consuming Men with a family history of infertility in first degree relatives Men with testicular atrophy Men with varicocele Men with changes in consistency and size of cord and vasodefran and epididymis Men with abnormalities in hormone or renal and liver tests Obese men with age less than 20-year old Obese men with age more than 45-year old Men without informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sperm indices including sperm volume evaluation, sperm count, motility rate and sperm morphology. Timepoint: One day before treatment and 3 months after treatment. Method of measurement: Spermogram test. | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum levels of testosterone. Timepoint: One day before treatment and 3 months after treatment. Method of measurement: Evaluation of venous blood sample based on laboratory kit.;Serum levels of estradiol. Timepoint: One day before treatment and 3 months after treatment. Method of measurement: Evaluation of venous blood sample based on laboratory kit. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactYadollah Ahmadi Asrbadr
Tabriz University of Medical Sciences
Outcome results
None listed