Termination of pregnancy. Pregnancy with abortive outcome
Conditions
Interventions
Intervention 1: In group A(control), vitamin B6, 40 mg, is inserted into the vagina in posterior fornix, and 4 hours later, misoprostol 400mcg, equivalent to two 200mcg tablets stained with saline wi
Placebo
Treatment - Other
In group A(control), vitamin B6, 40 mg, is inserted into the vagina in posterior fornix, and 4 hours later, misoprostol 400mcg, equivalent to two 200mcg tablets stained with saline will be inserted .
In group B(case) Isosorbide Mononitrate 40 mg, is inserted into the vagina in posterior fornix, and 4 hours later, Misoprostol 400mcg stained with saline will be inserted.
Sponsors
Research deputy Kermanshah University of Medical Sciences
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Gestational age 22-13 weeks can be a condition for entering the study. nulliparous Can be a condition for entering the study. Multiparous to parity 5 Can be a condition for entering the study. singleton pregnancy can be a condition for entering the study.
Exclusion criteria
Exclusion criteria: Women with contra indication of misoprostol (active Cardiac-pulmonary disease, Placenta Previa, history of 2 or more previous cesarean section, or history of major uterine surgeries such as myomectomy and uterine reconstruction surgery)Conditions for not admitting to study. Women with contraindication of Isosorbide mono nitrate (IMN) (sensitivity to nitrates, hypotension, hypovolemia, heart disease, significant anemia Hb below 7 gr / dl and closed angle glaucoma )Conditions for not admitting to study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The abortion rate is 12 hours. Timepoint: 12 hours later intervention. Method of measurement: View the disposal of pregnancy products.;The abortion rate is 24-12 hours. Timepoint: Abortion after 12 hours to 24 hours of intervention. Method of measurement: View the disposal of pregnancy products.;Abortion rate after 24 hours. Timepoint: In the 24th hour of the intervention. Method of measurement: View the disposal of pregnancy products. | — |
Secondary
| Measure | Time frame |
|---|---|
| Nausea. Timepoint: Every 4 hours after intervention until the Disposal of pregnancy products. Method of measurement: See Symptoms of the patient.;Vomiting. Timepoint: Every 4 hours after intervention until the disposal of pregnancy products. Method of measurement: See Symptoms of the patient.;Diarrhea. Timepoint: Every 4 hours after intervention until the disposal of pregnancy products. Method of measurement: See Symptoms of the patient.;Fever and chills. Timepoint: Every 4 hours after intervention until the disposal of pregnancy products. Method of measurement: See Symptoms of the patient.;Headache. Timepoint: Every 4 hours after intervention until the disposal of pregnancy products. Method of measurement: See Symptoms of the patient.;Heart beat. Timepoint: Every 4 hours after intervention until the disposal of pregnancy products. Method of measurement: See Symptoms of the patient.;Confusion. Timepoint: Every 4 hours after intervention until the disposal of pregnancy products. Method of measurement: See Symptoms of the patient. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr. Mona Khorami
Kermanshah University of Medical Sciences
Outcome results
None listed