Non-alcoholic fatty liver. Fatty (change of) liver, not elsewhere classified
Conditions
Interventions
Intervention 1: Intervention group: consumption of quinoa seeds for lunch instead of other grains and weight loss diet for 3 months. The amount of quinoa consumed for each person will be calculated ba
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: People with non-alcoholic steatohepatitis and Controlled Attenuation Parameter score more than 263 No history of alcohol abuse Absence of other diseases and chronic and acute liver disorders Absence of pregnancy, breastfeeding and menopause in women Not taking hepatotoxic drugs such as phenytoin, amoxifen and lithium Not having lost more than 8 percent weight in the last 6 months Blood pressure less than 140/90 mmHg No kidney disease Not using weight loss drugs No history of allergy to quinoa No history of cardiovascular diseases, diabetes and gastrointestinal disorders affecting absorption Absence of pituitary, thyroid disorders Willingness to participate in the study Not having clinically diagnosed psychiatric disorders that impair the patient's ability to provide written informed consent
Exclusion criteria
Exclusion criteria: Taking medicine or supplements that can affect the results Failure to accept study conditions pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Level of steatosis and liver fibrosis. Timepoint: At the beginning and 3 months after the start of the study. Method of measurement: Fibroscan. | — |
Secondary
| Measure | Time frame |
|---|---|
| Lipid profil. Timepoint: At the beginning of the study and at the end of the study (after 3 months). Method of measurement: blood sample.;Insulin sensitivity index. Timepoint: At the beginning of the study and at the end of the study (after 3 months). Method of measurement: math formula.;Insulin resistance index. Timepoint: At the beginning of the study and at the end of the study (after 3 months). Method of measurement: math formula.;Insulin concentration. Timepoint: At the beginning of the study and at the end of the study (after 3 months). Method of measurement: blood sample.;Anthropometric indices. Timepoint: At the beginning of the study and at the end of the study (after 3 months). Method of measurement: Tape measure, scale and mathematical formula.;Blood pressure. Timepoint: At the beginning of the study and at the end of the study (after 3 months). Method of measurement: Sphygmomanometer.;High-sensitivity C-reactive protein. Timepoint: At the beginning of the study and at the end of the study (after 3 months). Method of measurement: blood sample.;Liver enzymes alanine transaminase, aspartate aminotransferase,gamma-glutamyl tansferase. Timepoint: At the beginning of the study and at the end of the study (after 3 months). Method of measurement: blood sample. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAfsane GHolamrezayi
Shahid Beheshti University of Medical Sciences
Outcome results
None listed