irritable bowel syndrome. Irritable bowel syndrome
Conditions
Interventions
Intervention 1: Intervention group: will receive15 g (5 grams three times a day) L- glutamine supplement plus low FODMAP diet for 6 weeks. Intervention 2: Control group: will receive 15 g (5 grams thr
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Patients with irritable bowel syndrome, according to a gastroenterologist diagnosed according to ROME IV criteria (having at least one day a week over the past 3 months for at least two of the following: 1- related to Defecation; 2- related to the frequency of defecation, 3- related to changes in stool shape and consistency, and no pathological findings in gastrointestinal Body Mass Index in range (18-25) Lack of any organic intestinal disease ( diagnosed by last 5 years ago colonoscopy) and intestinal infection (diagnosed by stool culture) Lack of medical history of chronic gastrointestinal and colorectal disease Lack of any major bowel surgery Lack of medical history of liver disorders Absence of regular use of laxatives or antidiarrheal drugs No chronic use of corticosteroids and immunosuppressants No usage of drugs that modifying the digestive motility such as metoclopramide, cisapride, diphenoxylate No usage of drugs that increased bleeding of intestinal mucosa such as aspirin, warfarin and heparin Absence of nicotine and its derivatives use in the last 6 months No usage of NSAIDs and aspirin in last week (influence on gut permeability) Absence of severe mental or behavioral disorder Lack of medical history of kidney disorders
Exclusion criteria
Exclusion criteria: Not agree to entering the study Consumption of artificial sweeteners (effect on intestinal permeability) 2 days before entering the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Irritable Bowel Syndrome symptom severity score. Timepoint: Beginning and end of study. Method of measurement: Irritable Bowel Syndrome symptom severity scale Questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of life. Timepoint: Beginning and end of study. Method of measurement: Irritable bowel syndrome quality of life Questionnaire.;Serum zonulin. Timepoint: Beginning and end of the study. Method of measurement: Elisa kit.;Abdominal pain intensity. Timepoint: Beginning and end of the study. Method of measurement: Visual Analogue Scale.;Abdominal pain frequency. Timepoint: Beginning and end of the study. Method of measurement: Questionnaire.;Abdominal distension. Timepoint: Beginning and end of the study. Method of measurement: Visual Analogue Scale.;Satisfaction with bowel habits. Timepoint: Beginning and end of the study. Method of measurement: Visual Analogue Scale.;Interference with community function. Timepoint: Beginning and end of the study. Method of measurement: Visual Analogue Scale.;Defecation frequency. Timepoint: Beginning and end of study. Method of measurement: Questionnaire.;Defecation consistency. Timepoint: Beginning and end of study. Method of measurement: Questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAzita Hekmatdoost
Shahid Beheshti University of Medical Sciences
Outcome results
None listed