Irritable Bowel Syndrom. Other diseases of intestines
Conditions
Interventions
Intervention 1: Intervention group: 1) Group I: will receive food products with 8g/day gluten for first 2 weeks, 16g/day gluten for second 2 weeks, following 32g/day gluten for third 2 weeks. Interven
Sponsors
Shahid Beheshti University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 18-65 years Patients with irritable bowel syndrome, according to gastroenterologist diagnosed according to the ROME- IV criteria (1.Improvement with defecation 2.Onset associated with a change in stool frequency 3.Onset associated with a change in stool form (appearance) At least three days a month, three months a year and no pathological findings in the clinical investigating) lack of any organic intestinal disease(diagnosed by last 5 years ago colonoscopy) and intestinal infections(diagnosed by stool culture). No medical history of chronic gastrointestinal and colorectal disease Absence of any major bowel surgery Absence of regular use of laxatives or antidiarrheal drugs No chronic use of antibiotics, corticosteroids and immunosuppressants No usage of drugs that modifying the digestive motility such as metoclopramide, cisapride, diphenoxylate,… No usage of drugs that increased bleeding of intestinal mucosa such as aspirin, warfarin, heparin,… No history of breast cancer in patient or in first-degree relatives of a person Absence of severe mental or behavioral disorder Absence of nicotine and its derivatives use in last 6 months No usage of NSAIDs and aspirin in last week(influence on gut permeability)
Exclusion criteria
Exclusion criteria:
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Age. Timepoint: Beginning of study. Method of measurement: Question.;Gender. Timepoint: Beginning of study. Method of measurement: Observation.;Weight. Timepoint: Beginning and end of study. Method of measurement: Balance.;Height. Timepoint: Beginning and end of study. Method of measurement: Meter.;BMI. Timepoint: Beginning and end of study. Method of measurement: Calculation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Smoking. Timepoint: Beginning of study. Method of measurement: Question.;Type of diet. Timepoint: Beginning and end of study. Method of measurement: Data collection form.;Total Calorie Intake. Timepoint: Begining and end of the study. Method of measurement: Recall Questionare.;Total Carbohydrate Intake. Timepoint: Begining and end of the study. Method of measurement: Recall Questionare.;Total Protein Intake. Timepoint: Begining and end of the study. Method of measurement: Recall Questionare.;Total Fat Intake. Timepoint: Begining and end of the study. Method of measurement: Recall Questionare.;Total Fiber Intake. Timepoint: Begining and end of the study. Method of measurement: Recall Questionare.;Total MUFA Intake. Timepoint: Begining and end of the study. Method of measurement: Recall Questionare.;Total PUFA Intake. Timepoint: Begining and end of the study. Method of measurement: Recall Questionare.;Total SFA Intake. Timepoint: Begining and end of the study. Method of measurement: Recall Questionare.;IL-6. Timepoint: Begining and end of the study. Method of measurement: Enzymatic method using a kit.;INF-?. Timepoint: Begining and end of the study. Method of measurement: Enzymatic method using a kit. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Azita Hekmatdoost
Shahid Beheshti University of Medical Sciences
Outcome results
None listed