The effect of vitamin D supplementation in patients with ulcerative colitis

Study of the effect of vitamin D supplementation on serum vitamin D concentration, quality of life, disease activity index, and some of inflammatory and oxidative factors in patients with ulcerative colitis with vitamin D deficiency

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20100524004010N22

Enrollment

Registered

2018-02-01

Start date

2017-04-19

Completion date

Unknown

Last updated

2018-03-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ulcerative colitis. Ulcerative colitis, unspecified

Interventions

Intervention 1: vitamin D supplement for 12 weeks 2 pearl contain 1000 IU daily. Intervention 2: One vitamin D supplement 1000 IU daily and one pelacebo for 12 weeks.

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Cases with Ulcerative colitis Active mild to moderate disease severity No evident affliction with other intestinal diseases or disorders, inflammatory diseases and infectious diseases No history of taking supplements such as vitamin D multivitamin-mineral, omega-3, polyphenolic and antioxidants Not taking anti-coagulation drugs such as Heparin and Warfarin or NSAIDs (Non steroidal anti-inflammatory drugs), antihistamines and calcium channel antagonists such as Nifedipine within the past month Patients with vitamin d defficiency (less than 30 nano gram per mili liter) Body mass index (BMI) over than 18.5 and less than 30 kg/m2 Tendency to participate in this research No change in type & dose of drug usage during last month

Exclusion criteria

Exclusion criteria: Pregnancy or lactation in women or use of oral contraceptive drugs The patient Unwillingness to continue participation in this research Drug type and dosage change during intervention

Design outcomes

Primary

Measure	Time frame
Simple Clinical Colitis Activity Index. Timepoint: At the beginning and at the end of the study. Method of measurement: Simple Clinical Colitis Activity Index Questionnaire (SCCAIQ).;Quality of life. Timepoint: At the beginning and at the end of the study. Method of measurement: Inflammatory Bowel Disease Questionnaire -9 (IBDQ-9).;TNF-a. Timepoint: At the beginning and at the end of the study. Method of measurement: ELISA.;Hs-CRP. Timepoint: At the beginning and at the end of the study. Method of measurement: ELISA.;Serum TOC. Timepoint: At the beginning and at the end of the study. Method of measurement: kit.;Serum TAC. Timepoint: At the beginning and at the end of the study. Method of measurement: kit.	—

Measure

Time frame

Simple Clinical Colitis Activity Index. Timepoint: At the beginning and at the end of the study. Method of measurement: Simple Clinical Colitis Activity Index Questionnaire (SCCAIQ).;Quality of life. Timepoint: At the beginning and at the end of the study. Method of measurement: Inflammatory Bowel Disease Questionnaire -9 (IBDQ-9).;TNF-a. Timepoint: At the beginning and at the end of the study. Method of measurement: ELISA.;Hs-CRP. Timepoint: At the beginning and at the end of the study. Method of measurement: ELISA.;Serum TOC. Timepoint: At the beginning and at the end of the study. Method of measurement: kit.;Serum TAC. Timepoint: At the beginning and at the end of the study. Method of measurement: kit.

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Secondary

Measure	Time frame
Vitamin A intake. Timepoint: At the beginning and at the end of the study. Method of measurement: 24h recall questionnaire.;Carbohydrate intake. Timepoint: At the beginning and at the end of the study. Method of measurement: 24h recall questionnaire.;Weight. Timepoint: At the beginning and at the end of the study. Method of measurement: Scale.;Waist circumference. Timepoint: At the beginning and at the end of the study. Method of measurement: Metre.;Hip circumference. Timepoint: At the beginning and at the end of the study. Method of measurement: Metre.;Body Mass Index. Timepoint: At the beginning and at the end of the study. Method of measurement: Calculating.;Total energy intake. Timepoint: At the beginning and at the end of the study. Method of measurement: 24h recall questionnaire.;Protein intake. Timepoint: At the beginning and at the end of the study. Method of measurement: 24h recall questionnaire.;Total fat intake. Timepoint: At the beginning and at the end of the study. Method of measurement: 24h recall questionnaire.;PUFA fatty acid intake (omega 3). Timepoint: At the beginning and at the end of the study. Method of measurement: 24h recall questionnaire.;Cholesterol intake. Timepoint: At the beginning and at the end of the study. Method of measurement: 24h recall questionnaire.;Fiber intake. Timepoint: At the beginning and at the end of the study. Method of measurement: 24h recall questionnaire.;SFA fatty acid intake. Timepoint: At the beginning and at the end of the study. Method of measurement: 24h recall questionnaire.;MUFA fatty acid intake. Timepoint: At the beginning and at the end of the study. Method of measurement: 24h recall questionnaire.;PUFA fatty acid intake (omega 6). Timepoint: At the beginning and at the end of the study. Method of measurement: 24h recall questionnaire.;Vitamin E intake. Timepoint: At the beginning and at the end of the study. Method of measurement: 24h recall questionnaire.;VitaminC intake. Timepoint: At the beginning and	—

Measure

Time frame

Vitamin A intake. Timepoint: At the beginning and at the end of the study. Method of measurement: 24h recall questionnaire.;Carbohydrate intake. Timepoint: At the beginning and at the end of the study. Method of measurement: 24h recall questionnaire.;Weight. Timepoint: At the beginning and at the end of the study. Method of measurement: Scale.;Waist circumference. Timepoint: At the beginning and at the end of the study. Method of measurement: Metre.;Hip circumference. Timepoint: At the beginning and at the end of the study. Method of measurement: Metre.;Body Mass Index. Timepoint: At the beginning and at the end of the study. Method of measurement: Calculating.;Total energy intake. Timepoint: At the beginning and at the end of the study. Method of measurement: 24h recall questionnaire.;Protein intake. Timepoint: At the beginning and at the end of the study. Method of measurement: 24h recall questionnaire.;Total fat intake. Timepoint: At the beginning and at the end of the study. Method of measurement: 24h recall questionnaire.;PUFA fatty acid intake (omega 3). Timepoint: At the beginning and at the end of the study. Method of measurement: 24h recall questionnaire.;Cholesterol intake. Timepoint: At the beginning and at the end of the study. Method of measurement: 24h recall questionnaire.;Fiber intake. Timepoint: At the beginning and at the end of the study. Method of measurement: 24h recall questionnaire.;SFA fatty acid intake. Timepoint: At the beginning and at the end of the study. Method of measurement: 24h recall questionnaire.;MUFA fatty acid intake. Timepoint: At the beginning and at the end of the study. Method of measurement: 24h recall questionnaire.;PUFA fatty acid intake (omega 6). Timepoint: At the beginning and at the end of the study. Method of measurement: 24h recall questionnaire.;Vitamin E intake. Timepoint: At the beginning and at the end of the study. Method of measurement: 24h recall questionnaire.;VitaminC intake. Timepoint: At the beginning and

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAzita Hekmatdoost

Shahid Beheshti Nutrition Faculty

A_hekmat2000@yahoo.com+98 21 2237 6480

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026