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Evaluation the effect of atypical antipsychotic augmentation with Atomoxetine

The evaluation of atypical antipsychotic augmentation with Atomoxetine in the reduction of negative symptoms in patients with Schizophrenia

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20100520003979N9
Enrollment
60
Registered
2018-10-19
Start date
2018-10-23
Completion date
Unknown
Last updated
2019-01-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Schizophrenia. Schizophrenia

Interventions

Intervention 1: Intervention group: Atomoxetine is given 40 mg daily in the first week and 80 mg daily in the following weeks until 8 weeks. The effect of the medication on the negative symptoms in th

Sponsors

Ahvaz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Detection of schizophrenia based on the diagnosis of a faculty psychiatrist and an psychiatrist assistant with a clinical interview based on DSM-5 Bold negative symptoms( PANSS negative symptom sub-scale score more than 15) Not having liver disease Suffering from the disease for more than a year Age between 18 and 70 years.

Exclusion criteria

Exclusion criteria: Presence of Depression based on DSM-5 Clinical Interview Presence of Bipolar disorder Pregnant or lactating woman Substance abuse during the last month patients suffering from Attention Deficit Hyperactivity Disorder (ADHD)

Design outcomes

Primary

MeasureTime frame
Lack of social interest. Timepoint: At the beginning of the treatment and at 4th and 8th weeks. Method of measurement: PANSS scale.;Frivolity. Timepoint: At the beginning of the treatment and at 4th and 8th weeks. Method of measurement: PANSS scale.;Anhedonia. Timepoint: At the beginning of the treatment and at 4th and 8th weeks. Method of measurement: PANSS scale.;Loss of motivation. Timepoint: At the beginning of the treatment and at 4th and 8th weeks. Method of measurement: PANSS scale.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactForough Riahi

Ahvaz University of Medical Sciences

Riahi13@gmail.com+98 61 3374 3038

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026