Diabetic neuropathy. Diabetic autonomic neuropathy
Conditions
Interventions
Intervention 1: Intervention group: Olive leaf extract (capsule) is given orally three times a day for three consecutive months. Intervention 2: Control group: Pregabalin is prescribed orally twice a
Sponsors
Kermanshah University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Type I and II diabetic patients who have diabetes for at least one year and have diabetic neuropathy pain History of neuropathic pain for at least three months a pain score (VSA) equal to or greater than 4 at least 18 years of age or older HbA1c is equal to or less than 11
Exclusion criteria
Exclusion criteria: Pregnant and lactating women ischemic pain or other pain such as pains associated with amputation or arthritis Electroconvulsive Therapy in the past 30 days using warfarin, antiarrhythmic drugs, sedatives, hypnotices, anticonvulsants, NSAIDs and capsaicin in the past 7 days using antipsychotics, antidepressants, opioids and muscle relaxants during the past 14 days using anti-neuropathic drug and Unwillingness to stop taking it Dependence on alcohol or other drugs important metabolic diseases, cardiovascular diseases, thyroid disease, major blood diseases, reduced kidney function or liver function, bipolar disease, psychosis history of suicide drug sensitivity
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Quality of life score. Timepoint: At the beginning of the study and at the end of the third month of the study. Method of measurement: Quality of life questionnaire SF-36.;Diarrhea. Timepoint: during the study. Method of measurement: questionnaire of patient-reported side effects.;Stomach ache. Timepoint: during the study. Method of measurement: questionnaire of patient-reported side effects. | — |
Primary
| Measure | Time frame |
|---|---|
| Pain score on visual analog scale. Timepoint: At the end of each month for three consecutive months. Method of measurement: visual analog scale. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr Masoud Modarresi
Kermanshah University of Medical Sciences
Outcome results
None listed